GI Immunity

• Provides L-glutamine as essential fuel for immune cells including lymphocytes, neutrophils, and macrophages to support GALT function

• Supplies threonine, proline, and serine amino acids that form the peptide backbone of mucin for enhanced mucus production

• Research shows threonine supplementation increases goblet cell numbers and mucus secretion to house protective sIgA antibodies

• Increases CD4(+) and CD8(+) T cells in mesenteric lymph nodes, key immune structures in GALT

• Boosts secretory IgA production while improving gut structure and goblet cell numbers

• Balances immune responses by downregulating pro-inflammatory cytokines and upregulating anti-inflammatory ones

• Stimulates production of secretory IgA (sIgA), the gut's primary antibody for mucosal defense against pathogens

• Increases beneficial short-chain fatty acid production, particularly butyrate, which enhances mucus secretion and antimicrobial peptide production

• Produces anti-inflammatory factors that help restore immune balance and maintain mucosal homeostasis

• Supports mucin production and goblet cell numbers through L-threonine supplementation, enhancing the mucosal barrier that houses secretory IgA

• Fuels critical immune cells in GALT with glutamine, supporting lymphocyte proliferation and communication for optimal gut immune responses

• Increases beneficial Akkermansia bacteria and stimulates secretory IgA production through vitamin D3 supplementation

• Stimulates secretory IgA production, the gut's primary immune antibody that prevents pathogen attachment and neutralizes toxins

• Supports beneficial bacteria growth and SCFA production, which recruit regulatory T cells to reduce inflammation

• Provides glutamine fuel for immune cell division and function, essential for lymphocyte proliferation and communication

• Increases CD4+ T lymphocyte production in gut-associated lymphoid tissue while improving phagocyte activity of immune cells

• Stimulates macrophages to produce high levels of IL-12, promoting Th1-mediated immune responses and regulatory T-cell development

• Enhances secretory IgA production, the gut's main antibody that blocks pathogen adherence and neutralizes toxins

• Stimulates production of secretory IgA (sIgA), the gut's primary immune antibody that defends against pathogens and toxins

• Increases beneficial short-chain fatty acid production, particularly butyrate, which supports mucus secretion and antimicrobial peptide release

• Produces anti-inflammatory factors that help modulate immune responses and maintain mucosal homeostasis

• Increases regulatory T cells and IL-10 activation to support immune regulation and control inflammatory responses

• Stimulates macrophages to produce IL-12, promoting Th1-mediated immune responses and T cell production

• Enhances short-chain fatty acid production including butyrate, which supports mucus barrier integrity and antimicrobial peptide expression