Floramyces contains Saccharomyces cerevisiae (boulardii), a therapeutic probiotic yeast specifically designed to support individuals managing histamine intolerance, a condition where the body struggles to break down histamine due to impaired enzyme function.

Saccharomyces boulardii (SB) plays a crucial supportive role in increasing diamine oxidase (DAO) production, the primary enzyme responsible for breaking down histamine in the digestive tract [24]. In rat model studies, oral administration of S. boulardii significantly increased DAO activity in the small intestine compared to controls. This enhanced enzyme production is vital for histamine intolerance management, as reduced DAO activity is the primary cause of histamine accumulation in the body [24].

The mechanism behind S. boulardii's effectiveness lies in its ability to support intestinal mucosal health. Research demonstrates that SB supplementation leads to marked increases in mucosal polyamine concentrations, which are vital for mucosal cellular repair, proliferation, and maintenance [24]. Since DAO is produced by intestinal epithelial cells and these cells are protected by the mucosal layer, mucosal recovery fosters an environment conducive to intestinal cell health and subsequently improves DAO production [24].

This intestinal support is particularly important for histamine intolerance sufferers, as DAO is located primarily in the cells of the intestines and is responsible for breaking down histamine from food sources or histamine released from bacteria within the intestinal lumen [1][2]. When DAO function is impaired, histamine accumulates in the bloodstream and tissues, triggering symptoms such as abdominal discomfort, bloating, flushing, and fatigue [4][7]. By supporting the intestinal environment where DAO is produced, S. boulardii helps address one of the root causes of histamine intolerance rather than merely managing symptoms.