Autoimmunity

• Restores functional Treg populations after systemic inflammation through ceramide reduction and FOXP3 enhancement

• Reduces key inflammatory cytokines TNF-α and IL-6 that drive Treg dysfunction and autoimmune development

• Supports mitochondrial bioenergetics essential for naïve T cell commitment to regulatory T cell production

• Enhances regulatory T cell numbers and function by promoting FOXP3 expression, the master switch for immune tolerance

• Restores critical IL-2 levels essential for Treg survival and development under autoimmune conditions

• Significantly suppresses inflammatory cytokines IL-6 and TNF-α that drive autoimmune disease progression

• Vitamin D3 directly triggers FOXP3 expression and maintains IL-2 receptor function, essential for regulatory T cell survival and immune tolerance

• Zinc deficiency impairs Treg function quality - adequate levels optimize both Treg numbers and their suppressive capacity through IL-2 pathway support

• EGCG from green tea increases Treg numbers by promoting stable FOXP3 expression through beneficial epigenetic changes

• Suppresses IL-6 expression in multiple tissues, preventing inhibition of FOXP3 and supporting Treg development over pro-inflammatory TH17 cells

• Inhibits TNF-α production, protecting FOXP3 stability which is essential for Treg function and immune balance

• Stimulates IL-2 synthesis through T-cell activation, supporting Treg survival and maintaining immune tolerance