Clinical Benefits
Clinical Benefits
Regulatory T cells (Tregs) serve as critical immune system gatekeepers, functioning like brakes that restrain autoreactive immune responses and prevent damage to healthy tissues. When Tregs become functionally impaired or lose their stability, their suppressive capacity diminishes, leading to dysregulated immune activation and the onset or progression of autoimmune diseases [2]. Ginsana contains standardized G115® Panax ginseng extract, which demonstrates powerful immunomodulatory effects that directly address the underlying mechanisms of Treg dysfunction.
Panax ginseng demonstrates broad immunomodulatory capacity particularly beneficial for autoimmune diseases through its complex regulation of cytokines. Research shows that Panax ginseng consistently down-regulates IL-6 expression in tissues such as the spinal cord, colon, skin, and joints [40][41][42]. The suppression of IL-6 plays a critical role in shifting the immune balance from autoimmune to regulatory, as elevated IL-6 acts as a switch that interferes with FOXP3 induction, thereby inhibiting Treg development and promoting pro-inflammatory TH17 cells over Tregs [1][2][3].
In parallel to its IL-6 suppressing effects, Panax ginseng robustly inhibits TNF-α, another master pro-inflammatory cytokine implicated in the pathogenesis of autoimmune disease [40][41][42]. TNF-α contributes to autoimmunity by interfering with the stability of FOXP3, the master switch that allows Tregs to suppress excessive immune responses and maintain balance. Without stable FOXP3, Tregs lose their ability to control overactive immune cells effectively, leading to stronger and longer-lasting inflammation [6].
Mechanistically, these anti-inflammatory effects of Panax ginseng are largely mediated through the inhibition of key inflammatory signaling pathways, particularly NF-κB and MAPK signaling cascades, as well as suppression of STAT1 and STAT3 pathways [40][41][42]. Concurrently, Panax ginseng stimulates IL-2 synthesis, primarily by enhancing its secretion through activation of T-cells [40][41][42]. This is particularly important because IL-2 is essential for maintaining the expression of FOXP3 and supporting Treg survival, development, and function [8]. Chronic immune activation progressively depletes IL-2 availability, and this deficiency further destabilizes FOXP3 expression, exacerbating Treg collapse and loss of immune tolerance [21].
By simultaneously addressing the three core immune imbalances that drive Treg dysfunction - elevated IL-6, elevated TNF-α, and IL-2 deficiency - Panax ginseng makes an ideal candidate for autoimmune management at multiple checkpoints [40][41][42]. This multi-targeted approach helps restore the delicate balance needed for proper immune regulation and may help prevent the immune system from mistakenly attacking healthy tissues.
[1]>https://pubmed.ncbi.nlm.nih.gov/18510923/
[2]>https://pmc.ncbi.nlm.nih.gov/articles/PMC6066374/
[3]>https://pmc.ncbi.nlm.nih.gov/articles/PMC6280661/
[6]>https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.973813/full
[8]>https://www.nature.com/articles/ni.3540
[21]>https://ajp.amjpathol.org/article/S0002-9440(20)30250-9/fulltext
[40]>https://pmc.ncbi.nlm.nih.gov/articles/PMC6606836/
Ingredients
G115® Panax ginseng (Korean ginseng) ext.
equiv. Ginsenosides
ext. equiv. dry (root)
100 mg
4 mg
212.5 mg
Instructions
Instructions
Dosage
2 capsules in the morning
Duration
Long-term support for immune regulation and autoimmune correction
Warnings
Contains mannitol
Always read the label
Dietary supplements should not replace a balanced diet
If symptoms persist, worsen or change unexpectedly, consult your healthcare professional
Contraindications
Contraindications
This supplement may interact with the following categories of medications, as well as specific active ingredients.
• Estrogens
• Furosemide
• Imatinib
• Medications changed by the liver - refer list
• Medications for depression
• Medications for diabetes
• Medications that can cause an irregular heartbeat
• Medications that decrease the immune system
• Medications that slow blood clotting
• Midazolam
• Nifedipine
• Raltegravir
• Selegiline
• Warfarin
• Fexofenadine
Further details are provided below.
Please note that medications may be sold under different brand names, so check the listed active ingredients against your medication packaging.
Major Interactions
Moderate Interactions
Estrogens
• Oral contraceptive pill
• Estradiol
• Conjugated estrogens
• HRT combination products
Panax ginseng might have some of the same effects as estrogen. Taking Panax ginseng along with estrogen pills might decrease the effects of estrogen.
Furosemide
Panax ginseng might decrease how well furosemide works. But there isn't enough information to know if this is a big concern.
Imatinib
• Gleevec
Panax ginseng might decrease how quickly the liver breaks down imatinib. Taking Panax ginseng with imatinib might increase the effects and side effects of imatinib.
Insulin
Panax ginseng might decrease blood sugar. Insulin is also used to decrease blood sugar. Taking Panax ginseng along with insulin might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.
Medications changed by the liver
• Tramadol
• Metoprolol
• Fluoxetine
• Paroxetine
• Tamoxifen
• Amitriptyline
Some medications are changed and broken down by the liver. Panax ginseng might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
• Atorvastatin
• Simvastatin
• Amlodipine
• Diltiazem
• Cyclosporine
• Tacrolimus
• Midazolam
• Alprazolam
• Rivaroxaban
• Some HIV antiretrovirals
Medications for depression
• MAOIs
Taking Panax ginseng with MAOIs might increase the risk for certain side effects, such as anxiousness, headache, restlessness, and insomnia. Some common MAOIs include phenelzine, selegiline, and tranylcypromine.
Medications for diabetes
• Glyburide
• Glipizide
• Insulin
• Sitagliptin
• Empagliflozin
• Semaglutide
• Dapagliflozin
Panax ginseng might lower blood sugar levels. Taking panax ginseng along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications that can cause an irregular heartbeat
• QT interval-prolonging drugs
Panax ginseng might affect electrical currents in the heart. This can increase the risk of having an irregular heartbeat. Some medications can have this same effect. Taking panax ginseng with these medications might increase the risk for a serious heart issue.
Medications that decrease the immune system
• Cyclosporine
• Tacrolimus
• Mycophenolate
• Prednisone
• Methotrexate
• Azathioprine
Panax ginseng can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking panax ginseng along with these medications might decrease the effects of these medications.
Medications that slow blood clotting
• Heparin
• Rivaroxaban
• Apixaban
• Dabigatran
• Clopidogrel
Panax ginseng might slow blood clotting. Taking panax ginseng along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Midazolam
• Versed
Panax ginseng might increase how quickly the liver breaks down midazolam. Taking Panax ginseng with midazolam may decrease the effects of midazolam.
Nifedipine
• Procardia
Panax ginseng might affect how much nifedipine is available in the body. Taking Panax ginseng along with nifedipine might increase the effects and side effects of nifedipine.
Raltegravir
• Isentress
Raltegravir has been associated with liver toxicity in some people. Taking Panax ginseng with raltegravir might increase the risk of liver toxicity in some people taking raltegravir.
Selegiline
• Eldepryl
Panax ginseng might decrease or increase how much selegiline is absorbed by the body. This might change the effects and side effects of selegiline.
Stimulant drugs
Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Panax ginseng might also speed up the nervous system. Taking Panax ginseng along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with Panax ginseng.
• Jantoven
• Used for: blood thinning, clot prevention
Warfarin is used to slow blood clotting. Panax ginseng might decrease the effects of warfarin. But it's not clear if this interaction is a big problem. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Minor Interactions
Fexofenadine
• Allegra
Fexofenadine is taken to treat seasonal allergies. Panax ginseng might reduce how much fexofenadine is available in the body. But there isn't enough information to know if this is a big concern.
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• Suppresses IL-6 expression in multiple tissues, preventing inhibition of FOXP3 and supporting Treg development over pro-inflammatory TH17 cells
• Inhibits TNF-α production, protecting FOXP3 stability which is essential for Treg function and immune balance
• Stimulates IL-2 synthesis through T-cell activation, supporting Treg survival and maintaining immune tolerance