Hashimotos ThyrOiditIs

• Enhances regulatory T cell numbers and function by promoting FOXP3 expression, the master switch for immune tolerance

• Restores critical IL-2 levels essential for Treg survival and development under autoimmune conditions

• Significantly suppresses inflammatory cytokines IL-6 and TNF-α that drive autoimmune disease progression

• Astragalus demonstrated marked reduction in thyroid autoimmune antibodies (TPOAb and TGAb) in clinical studies with Hashimoto's patients

• Phytosterols suppress key inflammatory pathways that drive thyroid tissue destruction in autoimmune thyroiditis

• Astragalus improved immune balance by increasing regulatory T cells while reducing pro-inflammatory Th17 cells

• Regulates over 900 genes including many in immune cells, significantly upregulating antimicrobial proteins cathelicidin and β-defensin

• Promotes healthy macrophage polarization from inflammatory M1 to tissue-reparative M2 phenotype, supporting immune resolution

• Maintains optimal cytokine environment that enhances neutrophil pathogen-killing efficiency while protecting healthy tissues