Hashimotos ThyrOiditIs

• Directly induces cell death in autoreactive T cells targeting thyroid tissue

• Reduce pro-inflammatory cytokines, notably IL-17 and TNF-α, both of which are elevated in HT

• 8 week dosing has clinically demonstrated a reduction in thyroid antibodies by 50%

• Astragalus demonstrated marked reduction in thyroid autoimmune antibodies (TPOAb and TGAb) in clinical studies with Hashimoto's patients

• Phytosterols suppress key inflammatory pathways that drive thyroid tissue destruction in autoimmune thyroiditis

• Astragalus improved immune balance by increasing regulatory T cells while reducing pro-inflammatory Th17 cells

• Regulates over 900 genes including many in immune cells, significantly upregulating antimicrobial proteins cathelicidin and β-defensin

• Promotes healthy macrophage polarization from inflammatory M1 to tissue-reparative M2 phenotype, supporting immune resolution

• Maintains optimal cytokine environment that enhances neutrophil pathogen-killing efficiency while protecting healthy tissues