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CYP1 enzymes

CYP1 Inhibitors

 

  • Grapefruit (300mL juice)

  • Turmeric: to note turmeric has been found to be an inhibitor, but concentrated curcumin extract is an inducer.  

  • Quercetin, 500mg 

  • Chamomile Tea

  • Peppermint Tea

cyp2 enzymes

CYP2 Inhibitors:

 

  • Grapefruit Juice

  • Resveratrol, 1g per day

  • N-acetyl cysteine, over 1g daily

cyp3 enzymes

CYP3 Inhibitors:

 

  • Resveratrol, 1g daily 

  • Quercetin, 500 - 1000 mg daily

  • Grapefruit Juice, 600mL daily

For enzyme specific supplement recommendations please email us on:
info@remedylane-co.com.au

Hormones 

Oestradiol

Progesterone

Testosterone

Cortisol

Drugs: over 50% of all drugs

Statins: atorvastatin, simvastatin, and lovastatin

Calcium Channel Blockers: amlodipine, felodipine, and nifedipine

Benzos: diazepam, midazolam, and triazolam

Antibiotics: clarithromycin and erythromycin

Corticosteroids: prednisone and dexamethasone

Antiretrovirals: Several HIV medications, such as ritonavir and saquinavir

Antidepressants: including sertraline and nefazodone

Note: not limited to specific drugs mentioned

Reference
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488002/

Nutritional Support
Leucine
Isoleucine
Valine
B3
B6

Herbal Support
St Marys Thistle
Rosemary
Ginkgo Biloba
Echinacea
St John's Wort 

Dietary Support
Green Tea
Garlic
Broccoli

Nutritional Support
Leucine
Isoleucine
Valine
B2
B6
Indole 3 Carbinol

Herbal Support
St Marys Thistle 
Rosemary
Dandelion Root
Ginger

Dietary Support
Green Tea
Salmon, Trout, Krill, Shrimp 
Garlic
Cruciferous Vegetables

Carcinogens (cancer causing agents):

Heterocyclic Aromatic Amines (HAAs): Formed during the cooking of meat and fish at high temperatures

Nitrosamines: Found in cured meats, tobacco smoke, and some cosmetics.

Environmental Pollutants: Including dioxins, polychlorinated biphenyls (PCBs), and aromatic hydrocarbons

Mycotoxins: Certain fungal toxins, such as aflatoxin B1 are often found in contaminated foods and can be carcinogenic.

Aromatic Amines: Found in tobacco smoke, certain industrial chemicals, and some medications

Phase 1 [ CYP1 ] Enzymes Detoxify

Endogenous Compounds

Cholesterol

Oestradiol

Testosterone

Chemicals

Exhaust Fumes

Pesticides

Industrial Pollutants
Cigarette Smoke
Solvents
Paints & Adhesives
Colourings & dyes

Drugs, including but not limited to

Statins: atorvastatin, simvastatin, and lovastatin

Anti-inflammatory drugs: such as ibuprofen and diclofenac

Anticoagulants: Such as warfarin
Beta-blockers: Such as propranolol
Anticonvulsants: Such as phenytoin and carbamazepine
Antipsychotics: Such as haloperidol and clozapine
Antidepressants: Such as Prozac, Zoloft, and amitriptyline

CYP1 Specific Support

Phase 1 [ CYP2 ] Enzymes Detoxify

CYP2 Specific Support

Nutritional Support
Leucine
Isoleucine
Valine
B6

Herbal Support
St John's Wort
Ginkgo Biloba 

Supplemental
Indole 3 Carbinol
Curcumin

To note: Low CYP1 activity has been linked to higher risk of cancer. 
However, due to their rapid conversion to highly reactive intermediates, excessive activity of CYP1A enzymes without adequate phase II support may enhance the destructive effects of procarcinogens.

Phase 1 [ CYP3 ] Enzymes Detoxify

CYP3 Specific Support

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