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test

Mast Cell Profile

ANALYTES

Analytes are the substances measured in this test, which include:


  • Tryptase 

  • Chromogranin A

  • Histamine

rESULTS

sample Req.

Mast cell analyte levels are interpreted against reference ranges to determine whether concentrations fall within expected limits or demonstrate levels consistent with Mast cell activation or histamine intolerance.


  • Tryptase is a mast cell specific protease released during degranulation and is one of the most reliable markers of mast cell activation. Elevated tryptase indicates active mast cell activation and degranulation. Whereas normal or low levels of Trypase in conjunction with elevated histamine is more suggestive of histamine intolerance.


  • Chromogranin A is a secretory protein that elevates in states of increased mast cell mediator release. High levels can suggest heightened mast cell-related activation, particularly when consistent with compatible symptoms. 


  • Histamine is a primary mediator released from mast cells. Elevated plasma histamine may reflect excessive mast cell degranulation or histamine intolerance. For this reason, histamine levels are interpreted in conjunction with tryptase to help differentiate between mast cell activation and histamine intolerance.

Blood

cOST

$370

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The results of your health assessment have identified specific signs and symptoms that are clinically consistent with an increased risk of


  • Mast Cell Activation or Histamine Intolerance 


Mast Cell Activation or Histamine Intolerance are associated with a range of signs and symptoms, which have been clinically verified to include


  • Abdominal discomfort

  • Nausea

  • Heartburn / reflux

  • Diarrhoea or altered bowel habits

  • Reactions to wine

  • Reactions to nitrates in preserved meats

  • Reactions to cheese

  • Migraines

  • Sleep disturbances

  • Intense or vivid dreams

  • Motion sickness

  • Anxiety symptoms

  • Irritability

  • Sneezing

  • Persistent clear mucus

  • Overall chronic allergic reactions

  • Hives

  • Reactive or sensitive skin

  • Contact dermatitis

  • Facial and chest flushing

  • Swelling around the eyes

  • Low blood pressure

  • Lightheadedness or dizziness

  • Myalgia, muscle pain

  • Arthralgia, joint pain

  • Painful menstruation

  • Urinary urgency or frequency

  • Eye redness

  • Morning or persistent periorbital swelling

  • Warm skin

  • Profuse sweating

  • Fluctuating temperature sensations


This investigation is optional and may be used to verify the need for Mast Cell Activation or Histamine Intolerance intervention.


In the absence of testing, the treatment plan is tailored to address suspected contributors based on the presence of specific signs and symptoms and their degree of correlation with those contributors. If testing is undertaken, the assessment will be re-evaluated in accordance with the test results. You will be updated with the test results alongside any treatment revisions necessary.


It is important to recognise that mast cell activation and histamine intolerance share considerable symptomatic overlap. A distinguishing feature of histamine intolerance is gastrointestinal sensitivity following ingestion of histamine-rich foods, reflecting impaired histamine degradation rather than primary mast cell dysregulation. Given the clinical similarities between these conditions, appropriate laboratory assessment is recommended to aid in differentiation and guide targeted management.

A blood collection kit will be dispatched to you by post.


This collection kit must be presented to an affiliated pathology provider, where a qualified phlebotomist will perform the blood draw and arrange return of the specimen to the laboratory in accordance with standard handling protocols.


Affiliated pathology providers vary by Australian state. Please refer to the list below to identify the appropriate provider for your location:


  • VIC: Melbourne Pathology

  • NSW: 4Cyte Pathology

  • QLD: 4Cyte Pathology

  • SA: Abbott Pathology

  • WA: Western Diagnostic Pathology

  • NT: Western Diagnostic Pathology

  • TAS: TML Pathology

  • ACT: 4Cyte Pathology


Estimated Turnaround Time: 30 business days

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