CLINICALLY PROVEN;

SKIN:

• Higher production of dermal collagen to reduce and delay wrinkles

• Increases dermal thickness and skin elasticity

• Increases the skin moisture and hydration

• Reduce inflammatory processes in the skin

• Digestive healing effects

BONE / CARTILIAGE:

• Higher synthesis of the collagenous bone matrix

• Improves bone mineral density

• Activate the growth of new cartilage

• Reduces fracture rates

JOINTS / TENDONS:

• Improve collagen production in joints

• Reduces symptoms of pain and stiffness

• Improves joint function

• Reduced post-exercise joint pain

• Improved ankle stability

ABOUT GELITA® COLLAGEN PEPTIDES

GELITA® uses an enzymatic hydrolysis process to produce Bioactive Collagen Peptides (BCP's) from the parent collagen protein to be rapidly absorbed by the body. 

This process is similar to human digestion, however specific, so to consistently obtain the precise bioactive sequences. 

The BCPs by GELITA include a range of specific polypeptides of optimal molecular weight. The mode of action of BCPs is related to their unique molecular weight fingerprint, as they bind to specific receptors found on the surface of each cell type, stimulating the metabolism of the target cells. 

The specific molecular weight and structure of gelita peptides allows for optimal cell interaction and elicits long lasting activation and stimulation of the target cells. Each of the various GELITA® BCPs stimulate different cell types.

Whole Body Collagen contains the BCP's:

• VERISOL®

• FORTIBONE®

• FORTIGEL® 

VERISOL®

VERISOL® consists of special BCPs – which are important components for supporting healthy skin. Administered orally, VERISOL® influences the skin’s collagen metabolism directly from the inside. It increases the skin moisture and delays the formation of wrinkles.[15]

VERISOL® collagen peptide blend has been shown to upregulate synthesis of collagen, elastin and glycosaminoglycans in the dermal layer of facial skin, resulting in reduced wrinkles, improved skin elasticity and hydration.[14],[15]

The BCPs of VERISOL® are recognized by the fibroblast cells in the dermal layer of the skin as collagen fragments like those resulting from catabolic activities. The fibroblast cells they are stimulated to increase their collagen metabolism to counterbalance the pretended collagen degradation in the dermis. The result is a considerably higher production of dermal collagen.

VERISOL® RESEARCH

VERISOL® has also demonstrated the ability to improve cellulite appearance by increasing dermal thickness and elasticity.[38] These benefits may also be used in counteracting age-related skin thinning, manifested as ‘crepe’ like appearance.

Another study shows VERISOL® to reduce inflammatory processes in the skin, with potential for alleviating various clinical inflammatory conditions manifested in epithelial tissues.[7][8] 

Various collagen peptides have been shown to speed healing of bed sores in the elderly,[43] support healing of stomach ulcerations [40][41] and to have anti-inflammatory healing effects in colitis [39].

Women aged between 35 and 55 years revealed that VERISOL® leads to significantly higher skin elasticity – up to 15 % – compared to placebo treatment. This effect could be measured after just 4 weeks of treatment and persisted after 8 weeks of oral VERISOL® administration.

Another 4 weeks after the last intake of VERISOL® still showed higher skin elasticity levels than in the placebo treated group.

FORTIBONE®

The specific peptides of FORTIBONE® stimulate bone cells to increase the synthesis of bone components such as collagen. They have a kind of ‘signaling effect’ on osteoblasts to counterbalance the collagen degradation in the extracellular bone matrix, which is the essential framework for bone mineralization. 

In addition FORTIBONE® influences degenerative processes in bones by reducing osteoclast activity. The result is a considerably higher synthesis of collagenous bone matrix.

FORTIBONE® RESEARCH

Clinical, pre-clinical and in vitro research is accumulating to support the benefits of BCPs for bone health.[45]  This is complementary to the classical approach of ensuring adequate status for bone-supportive nutrients such as calcium, magnesium, silicon and vitamin D, K1 and K2.

In a study of menopausal women with osteopenia or osteoporosis, compared to placebo, supplementation with 5g per day of FORTIBONE® resulted in an improvement in bone mineral density (BMD) by 6.4% in the femoral neck and 5.5% in the spine, as well as increased markers of
bone formation (PINP), with no change in markers of bone breakdown (CTX 1).[28] The placebo group experienced no changes in BMD and PINP but showed no increase in CTX 1.

Another study showed that post-menopausal women who supplemented with 10g of collagen peptide blend (previous version of FORTIBONE®) for 3 years reported a fracture rate of just 9%, compared to 42% in a group treated only with calcium.[53] 

Another study supplemented a 10g dose of collagen peptides in conjunction with calcitonin and reported a higher reduction in bone resorption than in the intervention group with calcitonin alone.[29]

Animal studies have also demonstrated benefits of collagen peptide supplementation, including reduced fracture risk, increased BMD, organic mass and collagen content of bone, accelerated fracture healing and improved markers of bone turnover in ovariectomized rates and bone development during growth.[30-33],[36][45]

Based on evidence presented above, supplementation with FORTIBONE® demonstrates the potential to improve both essential components of bone – the minerals and the organic content, with emphasis on the collagen related matrix. Both of these aspects contribute to
the demonstrated reduction of fracture rate.[54]

FORTIGEL®

Optimized specific BCPs of FORTIGEL® have been proven to activate the growth of new cartilage by stimulating cells, helping to ease joint discomfort and make the joints smooth and mobile.

FORTIGEL® BCPs have been shown to improve collagen production in joints, resulting in improved cartilage structure (increased glycosaminoglycans content as evidenced by MRI and joint space by X-ray), reduced osteoarthritis symptoms (pain, stiffness), improved joint function, reduced post-exercise joint pain in young athletes and improved ankle stability.[16-26],[47],[48] 

Most athletic injuries occur at tendon sites, likely because the tendon is often the weakest link in the chain of transmitting mechanical force. Since the tendon is composed of 60-80% collagen, collagen peptide supplementation has potential to support improved tendon strength and elasticity.

FORTIGEL® RESEARCH

A study held at Penn State University (2008) with 147 athletes who experienced activity related joint pain. Subjects were divided into 2 groups, one taking 10g of FORTIGEL® collagen peptide per day and the other group taking placebo. The study was prospective, randomized, double-blind and placebo controlled. The study ran over a 24 week period. Both groups were assessed for several parameters referring to pain, mobility and inflammation.

Results showed significant changes with those taking the FORTIGEL® supplement across the following parameters when compared to placebo; reduced joint pain at rest (p=0.001), reduced joint pain when walking (p=0.003), reduced joint pain when standing (p=0.011), reduced joint pain when carrying objects (p=0.014), and reduced joint pain when lifting (p=0.018)

The results suggest that active people consuming FORTIGEL® can reduce parameters such as pain that has a negative effect on physical activity.[55]