CLINICALLY PROVEN;

• Supports carbohydrate metabolism

• Protection of the digestive mucosa

• Promotion of lactic acid-producing bacteria in the gut

• Stimulating effects on the intestinal mucosal immunity

• Preserve tight junctions in the small intestine

• Reduces the risk of anti-biotic associated diarrhoea by half

• Significantly increased eradication rates of H.Pylori (behind gastritis and reflux)

• Binding and removal of E. coli and Salmonella

• Protection against Clostridium difficile toxins

• Helps prevent relapses in Chron's disease

• Reduce symptoms of Ulcerative Colitis

• Effective treatment for parasitic (B. hominis) infection

CARBOHYDRATE METABOLISM

S. boulardii has been shown to stimulate enzymes of the intestinal brush-border, specifically, sucrase, lactase and maltase.[17], supporting the metabollism of the carbohydrates sucrose, lactose and maltose. 

GUT IMMUNITY 

S. boulardii helps preserve tight junctions in the small intestine, decreases inflammatory cytokine production in the gut, and stimulates increased sIgA levels and immune defence in the gut. Additionally, pathogenic bacteria adhere to S. boulardii in the intestinal lumen, resulting in decreased systemic invasion.[19]

ANTIBIOTIC-ASSOCIATED DIARRHOEA

In a placebo-controlled study on patients under antibiotic treatment, compelling results were obtained. Although S. boulardii does not suppress all antibiotic- associated diarrhoea, the fact that it reduces the risk by half is significant.[26][27]

HELICOBACTER PYLORI

S. boulardii may also be helpful for the eradication of H. pylori. A systematic review and meta-analysis showed that the addition of S. boulardii to standard H. pylori eradication treatments significantly increased eradication rates and decreased therapy-related side-effects.[15]

IRRITABLE BOWEL SYNDROME (IBS):

Additionally, S. boulardii has been shown to improve quality of life in patients with IBS-D when added to standard treatment with psyllium husk [16] compared to placebo with psyllium husk.

Research supports a potential synergy between S. boulardii [18] and mesalamine for IBS as well: S. boulardii alone did not significantly improve IBS symptoms, but given in combination with mesalamine, the improvement was greater than with mesalamine alone.[20]

CHRONS DISEASE 

Regarding Crohn’s disease, among a small cohort of Crohn’s patients in remission, 37.5% of those treated with the NSAID mesalamine for six months experienced a clinical relapse compared to 6.25% of those treated with mesalamine plus S. boulardii.

SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO)

A small clinical study in patients with SIBO and systemic sclerosis shows that adding Saccharomyces boulardii 200 mg twice daily for 14 days to metronidazole 500 mg twice daily for 7 days eradicates SIBO to a greater degree than metronidazole alone.[21]

ULCERATIVE COLITIS

Preliminary research shows that taking Saccharomyces boulardii 250 mg three times daily can reduce symptoms in patients with mild-to-moderate ulcerative colitis who experience a flare-up despite maintenance treatment with mesalamine (5-aminosalycilic acid, 5-ASA) 1 gram three times daily.[22]

PARASITIC INFECTION

A randomized single-blinded clinical trial included children presenting with gastrointestinal symptoms (abdominal pain, diarrhea, nausea-vomiting, flatulence) more than 2 weeks and confirmed B. hominis by stool examination.

The children were seperated into 3 groups: Group A, S. boulardii (250 mg twice a day). Group B, metronidazole (30 mg/kg twice daily). Group C, no treatment. 

At the end of the first month  clinical cure rate was 94.4% in group A, and 73.3% in group B (p = 0.11).[1]

Maintains a healthy gastrointestinal tract by:
Secreting polyamines (spermine and spermidine) that improve nutritional status and digestive capacity of the GIT, but also regenerate brush border damage and assist with enterocyte maturation, by stimulating the production of:
Brush border membrane digestive enzymes (lactase, maltase, sucrase)
Nutrient transporters (sodium-glucose transport proteins).

o increasing glucose intestinal absorption and mediating lactose breakdown o producing SCFAs for their antimicrobial, anti-inflammatory, immune

modulation and barrier function activities o stimulating protein and energy production.

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