• Strengthens the GI enteric immune system (GALT)

• SIBO eradication + recurrence prevention 

• Antibiotic-associated diarrhoea

• Alleviates infectious diarrhoea 

• Increases digestive enzyme activity

• H. pylori eradication

• Supports crohn’s disease relapse prevention

• Supports Ulcerative colitis

GI Immune Support (GALT)

Saccharomyces boulardii supports gastrointestinal and immune function through several synergistic mechanisms. It directly binds and inactivates pathogens such as E. coli, Salmonella, and Clostridium difficile via mannose-rich cell wall structures, preventing adhesion to the intestinal lining and neutralising bacterial toxins. 

It protects and restores gut barrier integrity during inflammation by preserving tight junction proteins and stabilising the mucosal surface. S. boulardii also modulates immunity by increasing secretory IgA, reducing pro-inflammatory cytokines, and stimulating brush-border digestive enzymes, which improves nutrient absorption and mucosal recovery. It further promotes a healthy microbiome by supporting lactic-acid–producing bacteria and is uniquely resistant to antibiotics, enabling use during antibiotic therapy. 

Helicobacter Pylori Infection   

Helicobacter pylori is a gram-negative bacterium that colonizes the gastric mucosa and drives low-grade chronic stomach inflammation. Saccharomyces boulardii is a beneficial yeast that exerts its anti-Helicobacter pylori effects primarily through indirect mechanisms that reduce bacterial colonization. First, it competes with H. pylori for adhesion sites on the gastric mucosa, thereby limiting the bacteria’s ability to attach and establish infection. Second, it produces antimicrobial substances such as short-chain fatty acids and specific enzymes that can inhibit bacterial growth or disrupt bacterial communication. Third, it enhances the protective function of the gastrointestinal barrier by stimulating mucin secretion, helping maintain mucosal integrity and resist H. pylori colonization. [32]