• Regulates Immune Activity 

• Alleviates Allergic Sensitivities 

• Alleviates Allergic Sinus Complaints

• Alleviates Rhinitis Symptoms

• Alleviates Eczema + Dermatitis + Hives

• Lowers Histamine Production + Related Conditions

• Supports Intestinal Barrier functioning

• Regulatory T Cells Support - Benefiting Autoimmunity

• Clinically proven for Chron’s disease

• Clinically proven for Ulcerative Colitis 

• Clinically proven for Rheumatoid Arthritis

Mast Cell Stabilsation - Inhibiting Histamine 

Lactobacillus paracasei acts directly on the gut-immune axis by interacting with gut-associated lymphoid tissue (GALT) to rebalance helper-T cell activity. It suppresses key Th2 cytokines, including IL-4, IL-5, and IL-13, which drive eosinophilic inflammation, IgE production, and allergic sensitisation. 

At the same time, L. paracasei enhances Th1 activity through increased IL-12 expression and promotes expansion of T-regulatory (Treg) cells, which release IL-10 and TGF-β to calm excessive immune activation. This dual action reduces serum IgE levels, inhibits mast-cell degranulation, and lowers histamine release, clinically translating to reduced reactivity in allergic and atopic conditions.

Lactobacillus rhamnosus GG provides additional mast-cell stabilising effects by reinforcing gut-barrier integrity. LGG tightens epithelial junctions, reduces antigen leakage, and decreases the immune triggers that normally activate mast cells. It further amplifies immune tolerance by increasing IL-10 and expanding Treg populations, which directly suppress IgE-driven pathways. 

LGG also downregulates pro-allergic cytokines IL-4 and IL-13, lowering IgE synthesis and reducing expression of high-affinity IgE receptors on mast cells. Together, these mechanisms lessen mast-cell priming, limit histamine release, and help restore balanced immune behaviour in individuals predisposed to allergic or inflammatory response.  [9][10][16][22]

Immune Regulation - Autoimmunity 

Lactobacillus paracasei LP-33 and Lactobacillus rhamnosus LGG work through complementary immunoregulatory pathways that help restore balance within the gut-immune axis. LP-33 interacts directly with gut-associated lymphoid tissue (GALT), where it influences antigen-presenting cells and promotes healthy T-cell differentiation. 

A key effect is also the expansion of T-regulatory cells (Tregs), which secrete the anti-inflammatory cytokines IL-10 and TGF-β. These signals suppress excessive Th2 activity, lower IgE production, and shift the immune profile toward a more regulated, tolerant state. 

Lactobacillus rhamnosus LGG reinforces many of these same pathways. By interacting with intestinal epithelial and dendritic cells via pattern-recognition receptors such as Toll-like receptors (TLRs), LGG stimulates robust IL-10 production and drives Treg differentiation. Heightened Treg activity suppresses IgE-mediated Th2 responses and helps regulate Th17-associated inflammation, promoting a state of immune tolerance and dampening inappropriate inflammatory signalling. 

LGG also strengthens mucosal homeostasis and barrier integrity, which reduces antigen penetration and further decreases immune reactivity.

Together, LP-33 and LGG promote a coordinated shift toward a Th1/Treg-dominant profile, reduce Th2-associated allergic signalling, lower IgE sensitivity, and support balanced, resilient immune function, beneficial in allergies, eczema, gut inflammation, autoimmunity and barrier dysfunction. [16]

Intestinal Permeability 

Both Lactobacillus paracasei LP-33 and Lactobacillus rhamnosus GG (LGG) support intestinal permeability, but through complementary mechanisms that work together to strengthen the gut barrier. LGG has a direct, clinically demonstrated effect on tightening epithelial junctions by upregulating proteins such as occludin, claudins, and ZO-1, lowering serum zonulin, reducing LPS translocation, and promoting rapid epithelial repair. These actions significantly decrease paracellular leak and improve mucosal integrity. 

Whereas LP-33 enhances barrier function more indirectly, by calming the immune-driven processes that damage the epithelium. It increases T-regulatory cell activity and IL-10, suppresses Th2 cytokines like IL-4, IL-5, and IL-13, reduces IgE-mediated mast-cell activation, and helps correct dysbiosis, all of which lower inflammatory stress on the intestinal lining. 

Together, LGG provides the structural tightening, while LP-33 provides the immune stabilisation that prevents ongoing barrier disruption, making the combination beneficial for individuals with intestinal permeability, allergy-linked gut inflammation, or immune-mediated mucosal dysfunction.