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L92

Lactobacillus acidophilus L-92

  • For Overall Skin inflammation 

  • Alleviates Eczema, Dermatitis, Hives and Reactive Facial Flushing


Lactobacillus acidophilus L-92 is a heat-killed probiotic with well-documented immunomodulatory effects, particularly in allergic and skin conditions. L-92 works by shifting immune activity away from an exaggerated Th2–IgE-driven response and toward a more regulated, tolerogenic profile. 


It reduces allergen-specific IgE production by downregulating Th2 cytokines (IL-4, IL-5, IL-13) and lowering thymus and activation-regulated chemokine (TARC), a key signal that drives allergic inflammation and recruits inflammatory cells into the skin. 


At the same time, L-92 enhances regulatory T-cell (Treg) activity and increases anti-inflammatory cytokines such as IL-10, helping restore immune intelligence to allergens. This dual action suppression of overactive Th2 pathways and strengthening of immune regulation reduces mast-cell sensitization and dampens the inflammatory cascade that fuels itch, redness, and barrier dysfunction in eczema.

ClInical Results

Eczema


Clinically, L-92 has been shown to significantly improve eczema severity when added to standard topical therapy. In a 6 month placebo-controlled trial in infants and toddlers with eczema and food allergy, only the L-92 group achieved a statistically significant reduction in severity scores compared to baseline. 


The probiotic group also demonstrated meaningful biomarker improvements, with significant reductions in TARC and total IgE relative to placebo, confirming a reduction in allergic-type immune activation. The placebo group, receiving topical treatment alone, did not show comparable changes. Overall, the study indicates that L-92 provides measurable adjunctive benefit, improving eczema severity beyond what topical therapy alone achieved. [20]

Supplement

Supplements containing L92

References

 

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC6704184/

[2] https://pubmed.ncbi.nlm.nih.gov/21983070/

[3] https://au.sfihealth.com/wp-content/uploads/2025/01/THER_WellMood_RO_APRIL24_v2-1.pdf

[4].https://www.sciencedirect.com/science/article/abs/pii/S0016508517355579

[5] https://pubmed.ncbi.nlm.nih.gov/29380647/

[6] https://pubmed.ncbi.nlm.nih.gov/31413153/

[7] https://pmc.ncbi.nlm.nih.gov/articles/PMC5658588/

[8] https://pmc.ncbi.nlm.nih.gov/articles/PMC10165082/

[9] https://pubmed.ncbi.nlm.nih.gov/14626627/

[10] https://pmc.ncbi.nlm.nih.gov/articles/PMC8306447/

[11] https://www.metagenicsinstitute.com.au/tech-data/lactobacillus-plantarum-299v

[12] https://www.metagenicsinstitute.com.au/tech-data/high-strength-researched-probiotic

[13].https://designsforhealth.com.au/wp-content/uploads/DFH_Saccharomyces-Boulardii_White-Paper_NEW_v1-1.pdf

[14].https://journals.lww.com/jcge/fulltext/2014/11001/can_lactobacillus_fermentum_lf10_and_lactobacillus.27.aspx

[15] https://brill.com/view/journals/bm/10/5/article-p483_1.xml

[16] https://pmc.ncbi.nlm.nih.gov/articles/PMC5592098/

[17] https://pmc.ncbi.nlm.nih.gov/articles/PMC4406132/

[18] https://pmc.ncbi.nlm.nih.gov/articles/PMC7770962/

[19] https://pmc.ncbi.nlm.nih.gov/articles/PMC8850513/

[20] https://pmc.ncbi.nlm.nih.gov/articles/PMC6494655/

[21].https://www.metagenicsinstitute.com.au/tech-data/Lactobacillus-rhamnosus-GR-1-and-Lactobacillus-reuteri-RC-14-liquorice-womens-urogenital-health

[22] https://www.researchgate.net/publication/330572707_

[23] https://www.metagenicsinstitute.com.au/tech-data/lp33-lgg-immune-control

[24].https://assets.contentstack.io/v3/assets/bltaf9269dac47f331a/blt77e65e5bd4cea986/66bc64647cb3ffcecd23bb61/Saccharomyces_boulardii.pdf

[25] https://link.springer.com/article/10.1186/s13223-024-00922-7

[26].https://www.researchgate.net/publication/312202040

[27] https://pmc.ncbi.nlm.nih.gov/articles/PMC6949908/

[28].https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/assessment-of-psychotropiclike-properties-of-a-probiotic-formulation-lactobacillus-helveticus-r0052-and-bifidobacterium-longum-r0175-in-rats-and-human-subjects/2BD9977C6DB7EA40FC9FFA1933C024EA

[29] https://www.mdpi.com/2072-6643/16/16/2779

[30] https://pmc.ncbi.nlm.nih.gov/articles/PMC8110190/

[31].https://academic.oup.com/femspd/article/55/3/324/496928

[32] https://pmc.ncbi.nlm.nih.gov/articles/PMC4733292/

  • Metagenics, UltraFlora Sensitive Skin Postbiotic 

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