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DSM 17938

Lactobacillus reuteri DSM 17938

  • Prevents Both Constipation + Loose Bowels


Constipation


Lactobacillus reuteri DSM 17938 supports intestinal hypermobility primarily by modulating the gut–brain–motility axis. It produces short-chain fatty acids (SCFAs) that stimulate colonic peristalsis and reduce intraluminal pH, which enhances motility. It also interacts with enteric nervous system pathways, increasing excitability of myenteric neurons via serotonin (5-HT) and BDNF modulation. 


Additionally, L. reuteri alters the composition of methane-producing microbiota by reducing Methanobrevibacter smithii, a key factor that normally slows transit; decreasing methane reduces inhibition of peristaltic waves, thereby normalising hypermobility or motility irregularity. [10]


Diarrhea


Lactobacillus reuteri DSM 17938 helps reduce and shorten diarrhea through several coordinated mechanisms. It restores microbiota balance disrupted by infection or antibiotics, adheres to intestinal epithelial cells, and produces antimicrobial compounds such as reuterin, which inhibits pathogenic bacteria including E. coli, Salmonella, C. difficile, and rotavirus. 


The strain also enhances mucin production, stabilising the mucosal barrier and preventing pathogen binding to enterocytes. It also strengthens epithelial tight junctions, reducing fluid loss into the lumen. Additionally, L. reuteri promotes regulatory T-cell activity, decreases intestinal inflammation, and reduces microbial translocation, all of which help resolve acute watery diarrhea more rapidly.  This multi-layered set of actions restores barrier integrity, reduces pathogen burden, and normalises fluid secretion and absorption. [10]

ClInical Results

Constipation 


Research has demonstrated that L. reuteri taken twice daily for four weeks had a significant increase in weekly bowel movements, along with reductions in abdominal discomfort, pain, and bloating. Another adult trial showed that L. reuteri reduced methane production, which correlated with improved stool frequency. Overall, supplementation produced meaningful increases in bowel movement frequency compared with baseline and placebo. [10]


Diarrhoea


Numerous clinical trials demonstrate that L. reuteri DSM 17938 significantly shortens the duration and severity of acute watery diarrhea. Administration of 1000 CFU decreased diarrhoea in children by day 2, with diarrhea persisted in only 48% of high-dose L. reuteri vs 80% of placebo. [10]

Supplement

Supplements containing DSM 17938

References

 

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC6704184/

[2] https://pubmed.ncbi.nlm.nih.gov/21983070/

[3] https://au.sfihealth.com/wp-content/uploads/2025/01/THER_WellMood_RO_APRIL24_v2-1.pdf

[4].https://www.sciencedirect.com/science/article/abs/pii/S0016508517355579

[5] https://pubmed.ncbi.nlm.nih.gov/29380647/

[6] https://pubmed.ncbi.nlm.nih.gov/31413153/

[7] https://pmc.ncbi.nlm.nih.gov/articles/PMC5658588/

[8] https://pmc.ncbi.nlm.nih.gov/articles/PMC10165082/

[9] https://pubmed.ncbi.nlm.nih.gov/14626627/

[10] https://pmc.ncbi.nlm.nih.gov/articles/PMC8306447/

[11] https://www.metagenicsinstitute.com.au/tech-data/lactobacillus-plantarum-299v

[12] https://www.metagenicsinstitute.com.au/tech-data/high-strength-researched-probiotic

[13].https://designsforhealth.com.au/wp-content/uploads/DFH_Saccharomyces-Boulardii_White-Paper_NEW_v1-1.pdf

[14].https://journals.lww.com/jcge/fulltext/2014/11001/can_lactobacillus_fermentum_lf10_and_lactobacillus.27.aspx

[15] https://brill.com/view/journals/bm/10/5/article-p483_1.xml

[16] https://pmc.ncbi.nlm.nih.gov/articles/PMC5592098/

[17] https://pmc.ncbi.nlm.nih.gov/articles/PMC4406132/

[18] https://pmc.ncbi.nlm.nih.gov/articles/PMC7770962/

[19] https://pmc.ncbi.nlm.nih.gov/articles/PMC8850513/

[20] https://pmc.ncbi.nlm.nih.gov/articles/PMC6494655/

[21].https://www.metagenicsinstitute.com.au/tech-data/Lactobacillus-rhamnosus-GR-1-and-Lactobacillus-reuteri-RC-14-liquorice-womens-urogenital-health

[22] https://www.researchgate.net/publication/330572707_

[23] https://www.metagenicsinstitute.com.au/tech-data/lp33-lgg-immune-control

[24].https://assets.contentstack.io/v3/assets/bltaf9269dac47f331a/blt77e65e5bd4cea986/66bc64647cb3ffcecd23bb61/Saccharomyces_boulardii.pdf

[25] https://link.springer.com/article/10.1186/s13223-024-00922-7

[26].https://www.researchgate.net/publication/312202040

[27] https://pmc.ncbi.nlm.nih.gov/articles/PMC6949908/

[28].https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/assessment-of-psychotropiclike-properties-of-a-probiotic-formulation-lactobacillus-helveticus-r0052-and-bifidobacterium-longum-r0175-in-rats-and-human-subjects/2BD9977C6DB7EA40FC9FFA1933C024EA

[29] https://www.mdpi.com/2072-6643/16/16/2779

[30] https://pmc.ncbi.nlm.nih.gov/articles/PMC8110190/

[31].https://academic.oup.com/femspd/article/55/3/324/496928

[32] https://pmc.ncbi.nlm.nih.gov/articles/PMC4733292/

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