Alleviates Acne

Bifidobacterium breve BR03, Lacticaseibacillus casei LC03, and Lactobacillus salivarius LS03 work synergistically to reduce acne by lowering inflammatory cytokines, suppressing pathogenic bacteria, and rebalancing both the gut–skin and skin microbiome.

B. breve BR03 reduces key acne-related cytokines such as IL-8 and TNF-α, calms systemic inflammatory signalling, and helps restore microbial balance in the gut and skin. It also exhibits mild antimicrobial activity against opportunistic bacteria that contribute to acne-associated dysbiosis. 

L. casei LC03 contributes antimicrobial defence by producing bacteriocins that directly inhibit Cutibacterium acnes and downregulates IL-8, helping to dampen the inflammatory cascade that drives lesion formation. 

L. salivarius LS03 further reinforces this anti-inflammatory effect by strongly suppressing IL-8 production and generating potent bacteriocins that inhibit C. acnes and Staphylococcus aureus, limiting both bacterial overgrowth and inflammatory activation.