Ulcerative Colitis 

Lp299v supplementation was administered to participants with ulcerative colitis. The results demonstrated  improved mucosal inflammation, reduced stool calprotectin and indicator of inflammation, enhanced microbial diversity, and supported symptomatic improvement. These findings suggest a clinically relevant mechanism in autoimmune management via cytokine suppression and improved Treg-mediated regulation of mucosal immunity. [8]

SIBO - Bloating + Gas 

Lp299v contributes to small-intestinal microbial balance by reducing pathogenic bacterial load, specifically lowering counts of E. coli and Salmonella through competitive adhesion to the intestinal mucosa and displacement of pathogenic organisms. The strain enhances mucin production, strengthening the physical barrier that prevents bacterial translocation and overgrowth within the small intestine. 

Additionally, Lp299v produces antimicrobial peptides, including plantaricins, that inhibit gram-negative and gram-positive pathogens, thereby decreasing luminal bacterial burden and limiting biofilm formation. Through these combined effects, Lp299v supports restoration of a healthier microbial community and mitigates mechanisms that contribute to SIBO-related symptoms. [8]

Iron Absorption 

In clinical research, across multiple human trials Lp299v increased iron absorption by an average of 20 - 70%, depending on the study design and test meal. When pooled in the meta-analysis, Lp299v produced a 40 - 70% improvement in iron absorption compared to control. This makes Lp299v the only probiotic with consistent, measurable, and clinically meaningful enhancement of iron absorption in humans. [27]

Intestinal Permeability

Studies have shown that supplementing with Lactobacillus plantarum 299v can significantly improve markers of intestinal permeability. Serum zonulin, a key indicator of tight-junction opening, decreased by 15 - 25 percent, reflecting stronger tight-junction integrity and reduced leakiness of the gut barrier. Additionally, inflammatory cytokines such as TNF-α and IL-6, both of which contribute to increased permeability, were lowered by 10 - 30 percent after supplementation, further supporting improved gut barrier function. [8]

Supplement