Clinical Benefits
Clinical Benefits
T-Clear is formulated to address hyperandrogenism, a hormonal condition characterized by excess testosterone and DHEA-S levels in women. This imbalance can manifest through irregular menstrual cycles, acne, hair loss, and metabolic dysfunction, making targeted nutritional support essential for hormonal restoration.
Myo-inositol serves as the cornerstone ingredient, directly targeting insulin-mediated testosterone production. Clinical research demonstrates that 4 grams daily for 12 weeks resulted in a 50% reduction in serum testosterone levels, alongside significant decreases in DHEA and luteinizing hormone (LH) [3]. In a separate study with 50 PCOS women, 2 grams of myo-inositol combined with 200 µg folic acid led to a 52% reduction in fasting insulin levels and a 56% decrease in insulin resistance [3]. When compared to metformin over six months, myo-inositol achieved comparable insulin-lowering effects while delivering superior reproductive benefits, including a 39% reduction in menstrual cycle length and improved oocyte quality from 35% to 82% [3].
Licorice extract (Glycyrrhiza glabra) provides powerful anti-androgenic effects through its active compound glycyrrhetinic acid, which inhibits 17β-hydroxysteroid dehydrogenase to limit testosterone synthesis from both adrenal and ovarian pathways. Clinical evidence shows that 3.5g daily for one month produces a 37% decrease in serum testosterone in healthy women [3][5]. Animal studies further demonstrate licorice's ability to restore follicle-stimulating hormone (FSH) levels, normalize LH/FSH ratios, and reverse ovarian abnormalities including follicular cysts and theca cell thickening [21]. Additional research shows licorice enhances oocyte maturation, fertilization rates, and embryo development [22].
White Peony (Paeonia lactiflora) complements these effects by targeting multiple pathways involved in testosterone regulation. It downregulates CYP17A1 and CYP11A1 enzymes responsible for testosterone production, enhances aromatase activity to convert testosterone into estrogen, and inhibits 5α-reductase to prevent conversion to the more potent DHT [3][5]. Clinical studies using approximately 7.5g over 2-3 months demonstrated 40-60% reductions in serum testosterone levels, improved menstrual regularity, and visible reductions in acne and hirsutism [3][5][23][24]. White Peony also improved ovarian morphology by reducing cystic follicles, increasing corpus luteum formation, and enhancing insulin sensitivity.
Chromium chloride hexahydrate provides chromium, an essential trace mineral that enhances insulin sensitivity and glucose metabolism, helping to address the insulin resistance commonly associated with hyperandrogenism. Folic acid supports cellular metabolism and works synergistically with inositol to optimize hormonal balance and reproductive function.
Ingredients
Inositol
1 g
Chromium chloride hexahydrate
equiv. Chromium
256 μg
50 μg
Folic acid
100 μg
Glycyrrhiza glabra (Licorice) ext.
ext. equiv. dry (root)
115 mg
1.5 g
Paeonia lactiflora (Peony) ext.
ext. equiv. dry (root)
150 mg
1.5 g
Instructions
Instructions
Dosage
2 tablets once daily
Duration
Minimum duration of 4 weeks, with continuation guided by symptoms
Suitable for long-term hyperandrogenism management
Warnings
Always read the label
Dietary supplements should not replace a balanced diet
If symptoms persist, worsen or change unexpectedly, consult your healthcare professional
If you have had a baby with neural tube defect/spina bifida, seek specific medical advice
Contraindications
Contraindications
This supplement may interact with the following categories of medications, as well as specific active ingredients.
• Digoxin
• Estrogens
• Medications changed by the liver - refer list
• Medications for high blood pressure
• Medications for inflammation
• Medications moved by pumps in cells - refer list
• Midazolam
• Paclitaxel
• Warfarin
• Diuretics
• Methotrexate
• Clozapine
• Medications that slow blood clotting
• Phenytoin
• Levothyroxine
• Medications for diabetes
• NSAIDs (non-steroidal anti-inflammatory drugs)
Further details are provided below.
Please note that medications may be sold under different brand names, so check the listed active ingredients against your medication packaging.
Major Interactions
Moderate Interactions
• Used for: heart failure, atrial fibrillation
Large amounts of licorice can decrease potassium levels in the body. Low potassium levels can increase the side effects of digoxin.
Estrogens
• Oral contraceptive pill
• Estradiol
• Conjugated estrogens
• HRT combination products
Licorice seems to change hormone levels in the body. Taking licorice along with estrogen might decrease the effects of estrogen.
Medications changed by the liver
• Cytochrome P450 2B6 substrates
Some medications are changed and broken down by the liver. Licorice might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
Medications changed by the liver
• Omeprazole
• Esomeprazole
• Clopidogrel
• Diazepam
• Escitalopram
• Sertraline
Medications changed by the liver
• Cytochrome P450 2C8 substrates
• Glipizide
• Phenytoin
• Losartan
• Atorvastatin
• Simvastatin
• Amlodipine
• Diltiazem
• Cyclosporine
• Tacrolimus
• Midazolam
• Alprazolam
• Rivaroxaban
• Some HIV antiretrovirals
Medications for high blood pressure
• Amlodipine
• Ramipril
• Perindopril
• Metoprolol
• Losartan
• Hydrochlorothiazide
Licorice might increase blood pressure. Taking licorice might reduce the effects of blood pressure medications. Monitor your blood pressure closely.
Medications for inflammation
• Corticosteroids
Licorice can decrease how quickly the body breaks down corticosteroids. This can increase the effects and side effects of corticosteroids.
Medications moved by pumps in cells
• P-glycoprotein substrates
Some medications are moved in and out of cells by pumps. Licorice might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Midazolam
• Versed
Licorice might increase how quickly midazolam is broken down by the body. This might decrease the effects of midazolam.
Paclitaxel
• Abraxane
• Onxol
• Taxol
• Used for: various cancers
Licorice might increase how quickly the body breaks down paclitaxel. Taking licorice with paclitaxel might decrease the effects of paclitaxel.
• Jantoven
• Used for: blood thinning, clot prevention
Warfarin is used to slow blood clotting. Licorice might decrease the effects of warfarin. Decreasing the effects of warfarin might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Diuretics
• Diuretic drugs
Licorice can decrease potassium levels. "Diuretics" can also decrease potassium levels. Taking licorice along with "Diuretics" might make potassium levels drop too low.
Diuretics
• Loop diuretics
Licorice can decrease potassium levels. Loop diuretics can also decrease potassium levels. Taking licorice and loop diuretics together might make potassium levels drop too low.
Clozapine
• Clozaril
Peony might increase the amount of clozapine in the body. Taking peony along with clozapine might increase the effects and side effects from clozapine.
Peony might have some of the same effects as estrogen. Taking peony along with estrogen might increase the effects and side effects from estrogen.
• Caffeine
• Clozapine
• Olanzapine
• Theophylline
• Tizanidine
• Duloxetine
• Ramelteon
Some medications are changed and broken down by the liver. Peony might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
Medications that slow blood clotting
• Heparin
• Rivaroxaban
• Apixaban
• Dabigatran
• Clopidogrel
Peony might slow blood clotting. Taking peony along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Phenytoin
Peony root might decrease the amount of phenytoin in the body. Taking peony root along with phenytoin might decrease the effects of phenytoin and increase the risk of seizures.
Insulin
Chromium might increase how well insulin works. Taking chromium along with insulin might cause your blood sugar to drop too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.
Levothyroxine
• Synthroid, others
Taking chromium with levothyroxine might decrease how much levothyroxine the body absorbs. This might make levothyroxine less effective. To help avoid this interaction, levothyroxine should be taken 30 minutes before or 3-4 hours after taking chromium.
Medications for diabetes
• Glyburide
• Glipizide
• Insulin
• Sitagliptin
• Empagliflozin
• Semaglutide
• Dapagliflozin
Chromium might lower blood sugar levels. Taking chromium along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Minor Interactions
Medications changed by the liver
• Caffeine
• Clozapine
• Olanzapine
• Theophylline
• Tizanidine
• Duloxetine
• Ramelteon
Some medications are changed and broken down by the liver. Licorice might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
Methotrexate
• Trexall
• Otrexup
• Rasuvo
• Used for: rheumatoid arthritis, psoriasis, certain cancers
Licorice might decrease how quickly the body breaks down methotrexate. This might increase the effects and side effects of methotrexate.
NSAIDs
• Ibuprofen
• Naproxen
• Diclofenac
• Celecoxib
• Aspirin
NSAIDs might increase chromium levels in the body and increase the risk of adverse effects. Avoid taking chromium supplements and NSAIDs at the same time.
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• Clinically proven 50% reduction in testosterone levels with myo-inositol supplementation in women with PCOS
• Licorice extract delivers 37% decrease in serum testosterone while normalizing ovarian hormone ratios
• White Peony provides 40-60% testosterone reduction alongside visible improvements in acne and excess hair growth