Clinical Benefits
Clinical Benefits
Remotiv contains Ze 117 Hypericum perforatum (St John's Wort) extract, a clinically researched botanical specifically formulated to support healthy serotonin levels and address symptoms of serotonin deficiency. When serotonin levels are inadequate, individuals may experience mood fluctuations, sleep disruption, digestive issues, and heightened emotional reactivity to everyday stressors.
St. John's Wort is one of the most extensively studied herbal treatments for low mood and depression, with its active compounds hyperforin and hypericin working to inhibit the reuptake of serotonin, dopamine, and norepinephrine. This mechanism effectively increases the amount of serotonin available in synaptic spaces throughout the brain. Biologically, St. John's Wort binds to neurotransmitter transporters in brain neurons, reducing serotonin reabsorption back into the presynaptic cell, which leads to prolonged serotonin activity at receptor sites.
Clinical studies have consistently demonstrated that St. John's Wort is more effective than placebo for mild-to-moderate depression and offers a favorable side-effect profile compared to conventional antidepressants. This enhanced serotonergic activity directly addresses many symptoms associated with serotonin deficiency, including mood instability, irritability, and the tendency toward exaggerated emotional reactions that occur when serotonin's normal regulatory buffer is weakened.
By supporting healthy serotonin levels, St. John's Wort helps restore the neurotransmitter's crucial role in stabilizing mood through its calming influence on stress and emotion processing circuits. Serotonin exerts this stabilizing effect in part through the 5-HT1A receptor, which dampens overactive excitatory signaling in key brain regions including the amygdala, hippocampus, and prefrontal cortex [1][2][3][5]. This enhanced serotonergic function helps reduce neuronal hyperexcitability, suppress excessive irritability, lower reactivity to sensory and emotional stimuli, and prevent maladaptive worry loops that characterize serotonin deficiency states.
Ingredients
Ze 117 Hypericum perforatum (St John's Wort) ext.
ext. equiv. dry (herb top flowering)
250 mg
1.38 g
Instructions
Instructions
Dosage
1 morning, 1 night
Duration
Suitable for long-term support of serotonin deficiency, with dosing adjusted according to symptoms
Warnings
Contains lactose
St John's wort affects the way many prescription medicines work, including the oral contraceptive pill. Consult your doctor.
Contains lactose and sugar.
If symptoms persist talk to your healthcare professional.
Dietary supplements should not replace a balanced diet
Patients taking high doses of St John's Wort are advised to avoid excessive exposure to sunlight or artificial UVA light
St John’s wort should be used cautiously in patients with known photosensitivity or in patients taking photosensitising agents
St John’s wort affects the way many prescription medicines work, including the oral contraceptive pill
Contraindications
Contraindications
This supplement may interact with the following categories of medications, as well as specific active ingredients.
• Birth control pills
• Cyclosporine
• Digoxin
• Docetaxel
• Imatinib
• Irinotecan
• Medications changed by the liver - refer list
• Medications for HIV/AIDS
• Medications moved by pumps in cells - refer list
• Mephenytoin
• Omeprazole
• Oxycodone
• Phenobarbital
• Phenprocoumon
• Phenytoin
• Rivaroxaban
• Tacrolimus
• Warfarin
• Bupropion
• Clopidogrel
• Clozapine
• Fexofenadine
• Finasteride
• Gliclazide
• Indinavir
• Ivabradine
• Medications that increase sensitivity to sunlight
• Medications used for lowering cholesterol
• Methadone
• Reserpine
• Serotonergic drugs
• Tramadol
• Voriconazole
• Zolpidem
• Ambrisentan
• Boceprevir
• Methylphenidate
Further details are provided below.
Please note that medications may be sold under different brand names, so check the listed active ingredients against your medication packaging.
Major Interactions
Birth control pills
• Contraceptive drugs
Some birth control pills contain estrogen. The body breaks down the estrogen in birth control pills to get rid of it. St. John's wort might increase the breakdown of estrogen. Taking St. John's wort along with birth control pills might decrease the effects of birth control pills. If you take birth control pills along with St. John's wort, use an additional form of birth control such as a condom.
Cyclosporine
• Restasis
• Used for: organ transplant, autoimmune conditions
The body breaks down cyclosporine to get rid of it. St. John's wort can increase how quickly the body breaks down cyclosporine. This might decrease how well cyclosporine works.
• Used for: heart failure, atrial fibrillation
St. John's wort might decrease how much digoxin the body absorbs. By decreasing how much digoxin the body absorbs, St. John's wort might decrease the effects of digoxin.
Docetaxel
• Taxotere
• Used for: breast, lung, prostate cancer
The body breaks down docetaxel to get rid of it. St. John's wort can increase how quickly the body breaks down docetaxel. This might decrease how well docetaxel works.
Imatinib
• Gleevec
The body breaks down imatinib to get rid of it. St. John's wort might increase how quickly the body gets rid of imatinib. Taking St. John's wort along with imatinib might decrease the effects of imatinib.
Irinotecan
• Camptosar
The body breaks down irinotecan to get rid of it. St. John's wort might increase how fast the body breaks down irinotecan. This might decrease the effects of irinotecan.
Medications changed by the liver
• Atorvastatin
• Simvastatin
• Amlodipine
• Diltiazem
• Cyclosporine
• Tacrolimus
• Midazolam
• Alprazolam
• Rivaroxaban
• Some HIV antiretrovirals
Some medications are changed and broken down by the liver. St. John's wort might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
Medications for HIV/AIDS
• Nonnucleoside Reverse Transcriptase Inhibitors
The body breaks down medications used for HIV/AIDS to get rid of them. St. John's wort can increase how quickly the body breaks down these medications. Taking St. John's wort might decrease how well some of these medications work.
• Protease Inhibitors
The body breaks down medications used for HIV/AIDS to get rid of them. Taking St. John's wort might increase how quickly the body breaks down these medications. Taking St. John's wort might decrease how well some of these medications work.
Medications moved by pumps in cells
• Dabigatran
• Cyclosporine
• Fexofenadine
• Loperamide
• Some HIV antiretrovirals
Some medications are moved in and out of cells by pumps. St. John's wort might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Mephenytoin
• Mesantoin
Mephenytoin is changed and broken down by the body. St. John's wort increases how quickly this medication is broken down by the body. This might decrease the effects of mephenytoin.
Omeprazole
The body breaks down omeprazole to get rid of it. St. John's wort can increase how quickly the body breaks down omeprazole. This could decrease the effects of omeprazole.
The body breaks down oxycodone to get rid of it. St. John's wort might increase how fast the body breaks down oxycodone. This might decrease the effects of oxycodone.
Phenobarbital
• Luminal
The body breaks down phenobarbital to get rid of it. St. John's wort might increase how quickly the body breaks down phenobarbital. This could decrease how well phenobarbital works and increase the risk of seizures.
Phenprocoumon
• Marcoumar, others
The body breaks down phenprocoumon to get rid of it. St. John's wort increases how quickly the body breaks down phenprocoumon. This decreases the effects of phenprocoumon.
Phenytoin
The body breaks down phenytoin to get rid of it. St. John's wort might increase how quickly the body breaks down phenytoin. This might decrease the effects of phenytoin and increase the possibility of seizures.
Rivaroxaban
The body breaks down rivaroxaban to get rid of it. St. John's wort can increase how quickly the body breaks down rivaroxaban. This can decrease the effects of rivaroxaban.
Tacrolimus
• Astagraf
• Used for: organ transplant anti-rejection
The body breaks down tacrolimus to get rid of it. St. John's wort can increase how quickly the body breaks down tacrolimus. This can decrease the effects of tacrolimus.
• Jantoven
• Used for: blood thinning, clot prevention
The body breaks down warfarin to get rid of it. St. John's wort might increase how quickly the body gets rid of warfarin. This might decrease the effects of warfarin and increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Moderate Interactions
Aminolevulinic acid
Aminolevulinic acid can make the skin sensitive to sunlight. St. John's wort might also increase sensitivity to sunlight. Taking St. John's wort along with aminolevulinic acid might increase the chances of sunburn, blistering or rashes on areas of skin exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.
Bupropion
The body breaks down bupropion to get rid of it. St. John's wort might increase how quickly the body breaks down bupropion. This might decrease the effects of bupropion.
Clopidogrel
The body must convert clopidogrel to its active form. Taking St. John's wort increases how quickly the body converts clopidogrel to the active form. This might increase the effects and side effects of clopidogrel, such as bruising and bleeding.
Clozapine
• Clozaril
The body breaks down clozapine to get rid of it. St. John's wort might increase how quickly the body breaks down clozapine. This might decrease how well clozapine works.
The body breaks down fentanyl to get rid of it. St. John's wort might increase how quickly the body gets rid of fentanyl. This might decrease the effects of fentanyl.
Fexofenadine
• Allegra
The body breaks down fexofenadine to get rid of it. St. John's wort might decrease how quickly the body gets rid of fexofenadine. This could increase the effects and side effects of fexofenadine.
Finasteride
• Proscar, Propecia
The body breaks down finasteride to get rid of it. St. John's wort might increase how quickly the body gets rid of finasteride. Taking St. John's wort along with finasteride might decrease its effects.
Gliclazide
• Diamicron, others
The body breaks down gliclazide to get rid of it. St. John's wort might increase how quickly the body gets rid of gliclazide. This might decrease the effects of gliclazide.
Indinavir
• Crixivan
The body breaks down indinavir to get rid of it. St. John's wort might increase how quickly the body breaks down indinavir. This might decrease the effects of indinavir.
Ivabradine
• Corlanor
The body breaks down ivabradine to get rid of it. St. John's wort might increase how fast the body breaks down ivabradine. This might decrease the effects of ivabradine.
Medications changed by the liver
• Caffeine
• Clozapine
• Olanzapine
• Theophylline
• Tizanidine
• Duloxetine
• Ramelteon
Some medications are changed and broken down by the liver. St. John's wort might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
• Cytochrome P450 2B6 substrates
• Omeprazole
• Esomeprazole
• Clopidogrel
• Diazepam
• Escitalopram
• Sertraline
• Glipizide
• Phenytoin
• Losartan
Medications that increase sensitivity to sunlight
• Photosensitizing drugs
Some medications might make the skin more sensitive to sunlight. St. John's wort might also make the skin more sensitive to sunlight. Using these products together might increase the risk of sunburn, blistering, or rashes when the skin is exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.
Medications used for lowering cholesterol
• Atorvastatin
• Rosuvastatin
• Simvastatin
• Pravastatin
• Fluvastatin
The body breaks down some medications to get rid of them. St. John's wort can increase how fast the body gets rid of some medications used for lowering cholesterol. Taking St. John's wort along with these medications might decrease their effects.
Methadone
• Dolophine
The body breaks down methadone to get rid of it. St. John's wort might increase how fast the body breaks down methadone. This might decrease the effects of methadone.
Procainamide
St. John's wort extract might increase how much procainamide the body absorbs. This could increase the effects and side effects of procainamide. But it's not clear if this is a big concern.
Reserpine
• Raudixin, others
Taking St. John's wort might decrease the effects of reserpine.
Serotonergic drugs
• Fluoxetine
• Sertraline
• Escitalopram
• Venlafaxine
• Duloxetine
• Tramadol
• MAOIs
St. John's wort might increase a brain chemical called serotonin. Some medications also have this effect. Taking St. John's wort along with these medications might increase serotonin too much. This might cause serious side effects including heart problems, seizures, and vomiting.
Tramadol
• ConZip
• Used for: moderate to severe pain
The body breaks down tramadol to get rid of it. St. John's wort might increase how fast the body breaks down tramadol. This might decrease the effects of tramadol.
Voriconazole
• Vfend
The body breaks down voriconazole to get rid of it. St. John's wort might increase how quickly the body gets rid of voriconazole. Taking St. John's wort along with voriconazole might decrease its effects.
Zolpidem
The body breaks down zolpidem to get rid of it. St. John's wort might increase how quickly the body breaks down zolpidem. Taking St. John's wort and taking zolpidem might decrease the effects of zolpidem.
Minor Interactions
Ambrisentan
• Letairis
The body breaks down ambrisentan to get rid of it. St. John's wort might increase how quickly the body gets rid of ambrisentan. But this effect is probably not a big concern.
Boceprevir
• Victrelis
St. John's wort contains a chemical called hypericin. Taking St. John's wort with boceprevir might increase the amount of hypericin in the body. This might increase the effects or side effects of St. John's wort.
Methylphenidate
• Concerta, others
Taking St. John's wort along with methylphenidate might decrease how well methylphenidate works. But it's not clear if this is a big concern.
Theophylline
The body breaks down theophylline to get rid of it. St. John's wort might increase how quickly the body gets rid of theophylline. Taking St. John's wort along with theophylline might decrease its effects in some people.
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• Contains clinically proven St. John's Wort extract that inhibits serotonin reuptake, increasing available serotonin in brain synapses
• More effective than placebo for mild-to-moderate depression with favorable side-effect profile compared to conventional antidepressants
• Helps stabilize mood by dampening overactive brain signaling and reducing emotional reactivity to everyday stressors