Clinical Benefits
Clinical Benefits
Herpes Simplex Latency involves the dormant state of HSV-1 and HSV-2 viruses that persist within sensory neurons, periodically reactivating to cause cold sores or genital herpes outbreaks. While the virus can reactivate on a daily basis with viral shedding, effective immune responses can often contain the virus before symptoms develop. Quercesorb contains quercetin phytosome technology designed to support the body's natural defenses against herpes simplex virus reactivation.
Quercetin, the primary active compound in Quercesorb, exhibits broad-spectrum antiviral activity against both HSV-1 and HSV-2 through multiple complementary mechanisms. In HSV-1 infections, quercetin disrupts viral attachment, downregulates the expression of key viral proteins, and suppresses viral gene transcription, thereby limiting viral replication. The flavonoid also modulates immune responses by inhibiting inflammatory signaling pathways commonly activated during HSV infections, which helps reduce virus-induced inflammation [8][9][10].
For HSV-2 specifically, quercetin demonstrates significant therapeutic potential by inhibiting viral replication by approximately 50%, primarily through downregulating essential viral genes involved in early infection and replication. Research shows it supports immune signaling pathways relevant to antiviral defense while limiting virus-induced cell death and dampening pro-inflammatory responses, contributing to reduced tissue damage during outbreaks [8][9][10].
Clinical evidence further supports quercetin's effectiveness in herpes management. In a clinical trial involving 68 individuals with oral herpes, an herbal blend containing 100 mg of quercetin and green tea extract administered daily over 2 to 36 months significantly reduced both the frequency and duration of HSV outbreaks. The supplement demonstrated greater safety and efficacy compared to standard antiviral medications like acyclovir and valacyclovir. Another study involving 139 individuals with genital herpes reported a remarkable 90.8% reduction in infection frequency using the same supplement over a 2-48 month period [10].
The phytosome delivery system in Quercesorb enhances quercetin's naturally poor bioavailability, potentially improving its therapeutic effects. Quercetin is naturally found in foods like capers (280mg per 100g), red onions (40mg per 100g), and kale (25mg per 100g), though supplementation provides more concentrated and bioavailable forms. The research suggests that quercetin's multi-target approach - inhibiting viral attachment, suppressing replication, and modulating inflammatory responses - makes it a valuable natural option for supporting immune defense against herpes simplex virus reactivation [8][9][10].
Ingredients
Indena quercetin phytosome
equiv. Quercetin dihydrate
250 mg
85 mg
Instructions
Instructions
Dosage
Prevention: 2 capsules daily
Infection: 4 capsules daily
Duration
Indicated for prevention and recommended at the onset of recurrent herpes simplex outbreaks.
Warnings
Avoid concurrent use with Digoxin medications
If you are pregnant, consult your healthcare practitioner before using this product
At doses typically administered for therapeutic purposes, quercetin is not associated with toxicity
Always read the label
Dietary supplements should not replace a balanced diet
If symptoms persist, worsen or change unexpectedly, consult your healthcare professional
Contraindications
Contraindications
This supplement may interact with the following categories of medications, as well as specific active ingredients.
• Cyclosporine
• Diclofenac
• Losartan
• Medications changed by the liver - refer list
• Medications for diabetes
• Medications for high blood pressure
• Medications moved by pumps in cells - refer list
• Midazolam
• Pravastatin
• Prazosin
• Quetiapine
• Sulfasalazine
• Warfarin
Further details are provided below.
Please note that medications may be sold under different brand names, so check the listed active ingredients against your medication packaging.
Major Interactions
Moderate Interactions
Cyclosporine
• Restasis
• Used for: organ transplant, autoimmune conditions
Quercetin might decrease how quickly the body breaks down cyclosporine. Taking quercetin with cyclosporine might increase the effects and side effects of cyclosporine.
• Voltaren, others
Quercetin might decrease how quickly the body breaks down diclofenac. Taking quercetin with diclofenac might increase the effects and side effects of diclofenac.
Losartan
• Cozaar
• Hyzaar
• Used for: high blood pressure, heart failure
Quercetin might change how the body absorbs and breaks down losartan. Taking quercetin with losartan might change the effects and side effects of losartan.
Medications changed by the liver
• Cytochrome P450 2C8 substrates
Some medications are changed and broken down by the liver. Quercetin might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
• Glipizide
• Phenytoin
• Losartan
• Tramadol
• Metoprolol
• Fluoxetine
• Paroxetine
• Tamoxifen
• Amitriptyline
• Atorvastatin
• Simvastatin
• Amlodipine
• Diltiazem
• Cyclosporine
• Tacrolimus
• Midazolam
• Alprazolam
• Rivaroxaban
• Some HIV antiretrovirals
Medications for diabetes
• Glyburide
• Glipizide
• Insulin
• Sitagliptin
• Empagliflozin
• Semaglutide
• Dapagliflozin
Quercetin might lower blood sugar levels. Taking quercetin along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications for high blood pressure
• Amlodipine
• Ramipril
• Perindopril
• Metoprolol
• Losartan
• Hydrochlorothiazide
Quercetin might lower blood pressure. Taking quercetin along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Medications moved by pumps in cells
• Organic Anion Transporter 1 Substrates
Some medications are moved in and out of cells by pumps. Quercetin might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
• Organic Anion Transporter 3 Substrates
• Organic anion-transporting polypeptide substrates
• P-glycoprotein substrates
Midazolam
• Versed
Quercetin might increase how quickly the body breaks down midazolam. Taking quercetin with midazolam might reduce the effects of midazolam.
Mitoxantrone
Quercetin might increase levels of mitoxantrone. Taking quercetin and mitoxantrone together might increase the effects and side effects of mitoxantrone.
Pravastatin
Quercetin might decrease how quickly the body gets rid of pravastatin. Taking quercetin with pravastatin might increase the effects and side effects of pravastatin.
Prazosin
• Minipress
Quercetin might increase levels of prazosin. Taking quercetin and prazosin together might increase the effects and side effects of prazosin.
Quetiapine
Quercetin might increase levels of quetiapine. Taking quercetin and quetiapine together might increase the effects and side effects of quetiapine.
Sulfasalazine
• Azulfidine
• Used for: Crohn's disease, ulcerative colitis, rheumatoid arthritis
Quercetin might increase levels of sulfasalazine. Taking quercetin and sulfasalazine together might increase the effects and side effects of sulfasalazine.
• Jantoven
• Used for: blood thinning, clot prevention
Quercetin might increase the effects that warfarin has on the body. Taking quercetin and warfarin together might increase the effects and side effects of warfarin, which could increase the risk of bruising and bleeding.
Minor Interactions
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• Reduces HSV-2 viral replication by approximately 50% through suppression of essential viral genes
• Clinical studies show 90.8% reduction in genital herpes infection frequency over 2-48 months
• Disrupts HSV-1 viral attachment and downregulates key viral proteins to limit replication