Clinical Benefits
Clinical Benefits
Dopamine deficiency can significantly impact cognitive function, memory formation, mood regulation, and overall brain health. This phospholipid complex provides targeted nutritional support through scientifically-backed ingredients that work synergistically to support dopamine synthesis, transport, and receptor function.
Vitamin B6, present in this formula as both pyridoxal 5-phosphate (P5P) and pyridoxine hydrochloride, plays a crucial role in dopamine synthesis by acting as a cofactor for the enzyme dopa-decarboxylase, which converts L-DOPA into dopamine [50]. B6 deficiency can directly disrupt dopamine production, making adequate levels essential for optimal neurotransmitter function. The inclusion of both the active P5P form and standard pyridoxine ensures comprehensive B6 support for dopamine synthesis pathways.
Choline bitartrate provides essential support for memory and cognitive function, particularly important given the interconnection between dopamine and memory systems. Research demonstrates that low dopamine has a mild association with significantly reduced memory, but when coupled with low acetylcholine (which choline supports), the effect becomes much more significant. Therefore, poor memory should be treated simultaneously with dopamine support and choline supplementation [15,16]. The inositol component further supports cellular membrane function and neurotransmitter signaling pathways.
The comprehensive B-vitamin complex, including thiamine (B1), riboflavin 5-phosphate (activated B2), nicotinamide and nicotinic acid (B3), calcium pantothenate (B5), biotin, cyanocobalamin (B12), and calcium folinate (activated folate), provides essential cofactors for neurotransmitter synthesis and energy metabolism. These B-vitamins work together to support the complex biochemical pathways involved in dopamine production and neural function, ensuring optimal brain energy metabolism and neurotransmitter balance.
This formulation addresses multiple aspects of dopamine support through its carefully selected phospholipid and vitamin complex. By targeting both the synthesis pathways and the supportive nutritional framework needed for optimal dopamine function, this supplement provides comprehensive support for individuals experiencing symptoms associated with dopamine deficiency, including attention difficulties, memory challenges, and mood imbalances.
Ingredients
Thiamine hydrochloride (Vitamin B1)
equiv. Thiamine
50 mg
44.6 mg
Riboflavin 5-phosphate sodium (Activated B2)
20 mg
Nicotinamide (Vitamin B3)
80 mg
Nicotinic acid (Vitamin B3)
20 mg
Pyridoxal 5-phosphate (P5P)
equiv. Pyridoxine
10 mg
6.38 mg
Pyridoxine hydrochloride (Vitamin B6)
equiv. Pyridoxine
20 mg
16.5 mg
Calcium pantothenate (Vitamin B5)
equiv. Pantothenic acid
164 mg
150 mg
Choline bitartrate
100 mg
Inositol
100 mg
Biotin
500 μg
Cyanocobalamin (Vitamin B12)
500 μg
Calcium folinate (Activated folate)
equiv. Folinic acid
521 μg
400 μg
Instructions
Instructions
Dosage
1 capsule daily with meals
Duration
Minimum 8 weeks
Indicated for long-term management in individuals over 45 years of age
Warnings
If pregnant or likely to become pregnant, consult your health professional before use
Always read the label
Dietary supplements should not replace a balanced diet
If symptoms persist, worsen or change unexpectedly, consult your healthcare professional
Contains vitamin B6; stop taking this medication if you experience tingling, burning or numbness and see your healthcare practitioner as soon as possible
People sensitive to nicotinic acid may experience flushing of the skin; however, the flush is generally mild and transient
Contraindications
Contraindications
This supplement may interact with the following categories of medications, as well as specific active ingredients.
• Allopurinol
• Gemfibrozil
• Medications for diabetes
• Medications for high blood pressure
• Medications that can harm the liver
• Medications that slow blood clotting
• Medications used for lowering cholesterol
• Nicotine patch
• Probenecid
• Sulfinpyrazone
• Warfarin
Further details are provided below.
Please note that medications may be sold under different brand names, so check the listed active ingredients against your medication packaging.
Major Interactions
Moderate Interactions
Allopurinol is used to treat gout. Taking large doses of niacin might worsen gout and decrease the effects of allopurinol.
Gemfibrozil
• Lopid
Taking niacin along with gemfibrozil might increase the risk for muscle damage in some people. Use with caution.
Medications for diabetes
• Glyburide
• Glipizide
• Insulin
• Sitagliptin
• Empagliflozin
• Semaglutide
• Dapagliflozin
High doses of niacin might increase blood sugar levels. Taking niacin along with diabetes medications might reduce the effects of these medications. Monitor your blood sugar closely.
Medications for high blood pressure
• Amlodipine
• Ramipril
• Perindopril
• Metoprolol
• Losartan
• Hydrochlorothiazide
Niacin might lower blood pressure. Taking niacin along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Medications that can harm the liver
• Acetaminophen / Paracetamol
• Methotrexate
• Atorvastatin
• Simvastatin
• Isoniazid
Niacin might harm the liver. Some medications can also harm the liver. Taking niacin along with a medication that can harm the liver might increase the risk of liver damage.
Medications that slow blood clotting
• Heparin
• Rivaroxaban
• Apixaban
• Dabigatran
• Clopidogrel
Niacin might slow blood clotting. Taking niacin along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications used for lowering cholesterol
• Bile acid sequestrants
Some medications called bile acid sequestrants can decrease how much niacin the body absorbs. This might reduce the effects of niacin. Take niacin and these medications at least 4-6 hours apart.
• Atorvastatin
• Rosuvastatin
• Simvastatin
• Pravastatin
• Fluvastatin
Taking niacin along with statins might increase the risk for muscle damage in some people. Use with caution.
Nicotine patch
• Nicoderm
Niacin can sometimes cause flushing and dizziness. Nicotine patches can also cause flushing and dizziness. Taking niacin and using a nicotine patch may increase the risk of flushing and dizziness.
Probenecid
• Benemid
Probenecid is used to treat gout. Taking large doses of niacin might worsen gout and decrease the effects of probenecid.
Sulfinpyrazone
• Anturane
Sulfinpyrazone is used to treat gout. Taking large doses of niacin might worsen gout and decrease the effects of sulfinpyrazone.
Thyroid hormone
The body naturally produces thyroid hormones. Niacin might decrease thyroid hormone levels. Taking niacin with thyroid hormone pills might decrease the effects of thyroid hormone.
• Jantoven
• Used for: blood thinning, clot prevention
Niacin might increase the blood thinning effects of warfarin and potentially increase the chance of bleeding. Your healthcare provider may need to monitor you more often if you take niacin along with warfarin. The dose of your warfarin medication may need to be changed.
Minor Interactions
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• Vitamin B6 acts as a crucial cofactor for dopa-decarboxylase, the enzyme that converts L-DOPA into dopamine
• Choline supplementation is clinically recommended alongside dopamine support for optimal memory function
• Activated B-vitamin forms provide superior bioavailability for neurotransmitter synthesis pathways