Medications changed by the liver

• Glucuronidated drugs

Some medications are changed and broken down by the liver. Calcium D-glucarate might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.

Medications for cancer

• Doxorubicin

• Bleomycin

• Daunorubicin

• Mitomycin

• Epirubicin

Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.

Medications that slow blood clotting

• Heparin

• Rivaroxaban

• Apixaban

• Dabigatran

• Clopidogrel

Alpha-lipoic acid might slow blood clotting. Taking alpha-lipoic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Thyroid hormone

Alpha-lipoic acid seems to decrease how well thyroid hormone works in the body. Taking alpha-lipoic acid with thyroid hormone might decrease the effects of the thyroid hormone.

• Jantoven

• Used for: blood thinning, clot prevention

Chlorella contains large amounts of vitamin K. Vitamin K is used by the body to help the blood clot. Warfarin is used to slow blood clotting. Chlorella might decrease the effects of warfarin. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.

Medications for high blood pressure

• Amlodipine

• Ramipril

• Perindopril

• Metoprolol

• Losartan

• Hydrochlorothiazide

Taurine might lower blood pressure. Taking taurine along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

• Omeprazole

• Esomeprazole

• Clopidogrel

• Diazepam

• Escitalopram

• Sertraline

Some medications are changed and broken down by the liver. Artichoke might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.

Medications for diabetes

• Glyburide

• Glipizide

• Insulin

• Sitagliptin

• Empagliflozin

• Semaglutide

• Dapagliflozin

Artichoke might lower blood sugar levels. Taking artichoke along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Artichoke might lower blood pressure. Taking artichoke along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Coriander might lower blood pressure. Taking coriander along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Medications that increase sensitivity to sunlight

• Photosensitizing drugs

Some medications might make the skin more sensitive to sunlight. Coriander might also make the skin more sensitive to sunlight. Using these products together might increase the risk of sunburn, blistering, or rashes when the skin is exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.

Sedative medications

• Diazepam

• Alprazolam

• Temazepam

• Zolpidem

• Zopiclone

• Promethazine

Coriander might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking coriander with sedative medications might cause breathing problems and/or too much sleepiness.

Triclabendazone

• Egaten

Theoretically, barley might decrease the clinical effects of triclabendazole.

Animal research suggests that a diet supplemented with barley can reduce the bioavailability of triclabendazole when taken concomitantly. This effect has not been shown in humans.

Aluminum

Aluminum is found in most antacids. Vitamin C can increase how much aluminum the body absorbs. However, it is not clear if this interaction is a big concern. Take vitamin C two hours before or four hours after antacids.

Estrogens

• Oral contraceptive pill

• Estradiol

• Conjugated estrogens

• HRT combination products

Vitamin C might decrease how quickly the body gets rid of estrogens. Taking vitamin C along with estrogens might increase the effects and side effects of estrogens.

Fluphenazine

• Prolixin

Large amounts of vitamin C might decrease how much fluphenazine is in the body. Taking vitamin C along with fluphenazine might decrease the effectiveness of fluphenazine.

Indinavir

• Crixivan

Taking large amounts of vitamin C along with indinavir might decrease how much indinavir stays in the body. It's not clear if this interaction is a big concern.

Levothyroxine

• Synthroid, others

Taking vitamin C along with levothyroxine might increase how much levothyroxine the body absorbs. This can increase the amount of levothyroxine in the body and increase its effects and side effects.

• Cyclophosphamide

• Chlorambucil

• Melphalan

• Busulfan

• Temozolomide

Vitamin C is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking vitamin C.

Vitamin C is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking vitamin C.

Niacin

Taking niacin with vitamin C and other antioxidants can decrease the effects of niacin on good cholesterol levels. It is unknown if vitamin C alone decreases the effects of niacin on good cholesterol levels.

Warfarin is used to slow blood clotting. Large amounts of vitamin C might decrease the effects of warfarin. Decreasing the effects of warfarin might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.

Choline Magnesium Trisalicylate

• Trilisate

Rosemary contains chemicals that are similar to choline magnesium trisalicylate. Taking rosemary along with choline magnesium trisalicylate might increase the effects and side effects of choline magnesium trisalicylate.

Rosemary might lower blood sugar levels. Taking rosemary along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Rosemary might slow blood clotting. Taking rosemary along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Salsalate

• Disalcid

Salsalate is called a salicylate. Rosemary also contains a salicylate. Taking salsalate with rosemary might increase the risk for side effects from salicylates.

Ledipasvir

Taking milk thistle might decrease how quickly the body breaks down ledipasvir. This might increase the effects and side effects of ledipasvir.

• Cytochrome P450 2B6 substrates

Some medications are changed and broken down by the liver. Milk thistle might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.

Medications changed by the liver

• Glucuronidated drugs

Milk thistle might lower blood sugar levels. Taking milk thistle along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Medications moved by pumps in cells

• P-glycoprotein substrates

Some medications are moved in and out of cells by pumps. Milk thistle might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Milk thistle might affect levels of morphine in the blood. This might increase or decrease the effects and side effects of morphine.

Raloxifene

• Evista

Taking milk thistle might decrease how well the body breaks down raloxifene in the stomach. This might increase the effects and side effects of raloxifene.

Sirolimus

• Rapamune

Taking milk thistle might decrease how well the liver breaks down sirolimus. This might increase the effects and side effects of sirolimus.

Sofosbuvir

Taking milk thistle might increase how quickly the body breaks down sofosbuvir. This might decrease the effects of sofosbuvir.

Tamoxifen

• Soltamox

• Used for: breast cancer treatment and prevention

Milk thistle might increase how much tamoxifen is absorbed by the body. This might increase the effects and side effects of tamoxifen.

Warfarin is used to slow blood clotting. Taking milk thistle might increase the effects of warfarin, which could increase the risk of bleeding.

Antibiotics

• Doxycycline

• Ciprofloxacin

• Amoxicillin

• Azithromycin

• Norfloxacin

• Trimethoprim

Zinc might decrease how much antibiotic the body absorbs from the gut. Taking zinc along with quinolone antibiotics might decrease the effects of these antibiotics. To avoid this interaction, take antibiotics at least 2 hours before or 4-6 hours after zinc supplements.

Zinc can decrease the amount of tetracyclines the body absorbs. Taking zinc with tetracyclines might decrease the effects of tetracyclines. To avoid this interaction, take tetracyclines 2 hours before or 4-6 hours after taking zinc supplements.

Bictegravir/emtricitabine/tenofovir alafenamide

• Biktarvy

In theory, zinc might decrease how much bictegravir/emtricitabine/tenofovir alafenamide the body absorbs from the stomach. To avoid this interaction, take bictegravir/emtricitabine/tenofovir alafenamide at least 2 hours before or 6 hours after zinc containing products.

Cephalexin

• Keflex

Zinc can reduce how much cephalexin the body absorbs. This might decrease how well cephalexin works for treating infections. To avoid this interaction, take zinc 3 hours after taking cephalexin.

Cisplatin

• Platinol-AQ

Cisplatin is used to treat cancer. Taking zinc along with cisplatin might inactivate cisplatin therapy. But it's not clear if this is a big concern.

Medications for HIV/AIDS

• Integrase inhibitors

Taking zinc along with integrase inhibitors might decrease blood levels of integrase inhibitors. This might decrease the effects of these medications. Talk to your healthcare provider if you are using integrase inhibitors and want to start taking zinc.

Penicillamine

• Cuprimine, Depen

Zinc might decrease how much penicillamine the body absorbs. Taking zinc with penicillamine might decrease the effects of penicillamine. Take zinc and penicillamine at least 2 hours apart.

Ritonavir

• Norvir

Ritonavir is a drug used for HIV infection. Zinc can reduce how much ritonavir the body absorbs. But it isn't clear if this is a big concern.

Cyclosporine

• Restasis

• Used for: organ transplant, autoimmune conditions

Schisandra might decrease how quickly the body breaks down cyclosporine. Taking schisandra with cyclosporine might increase the effects and side effects of cyclosporine.

Some medications are changed and broken down by the liver. Schisandra might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.

• Glipizide

• Phenytoin

• Losartan

• Atorvastatin

• Simvastatin

• Amlodipine

• Diltiazem

• Cyclosporine

• Tacrolimus

• Midazolam

• Alprazolam

• Rivaroxaban

• Some HIV antiretrovirals

Some medications are moved in and out of cells by pumps. Schisandra might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Midazolam

Schisandra might decrease how quickly the body breaks down midazolam. Taking schisandra along with midazolam might increase the effects and side effects of midazolam.

Sirolimus

• Rapamune

Schisandra might decrease how quickly the body breaks down sirolimus. Taking schisandra along with sirolimus might increase the effects and side effects of sirolimus. Talk with your healthcare provider if you are taking sirolimus.

Tacrolimus

• Astagraf

• Used for: organ transplant anti-rejection

Schisandra might decrease how quickly the body breaks down tacrolimus. Taking schisandra with tacrolimus might increase the amount of tacrolimus in your body and the effects and side effects of tacrolimus. Talk with your healthcare provider before using this combination.

Talinolol

• Cordanum

• Used for: angina, heart conditions

Schisandra might increase the amount of talinolol in the body. Taking schisandra while taking talinolol might increase the effects and side effects of talinolol.

Voriconazole

• Vfend

Schisandra might decrease how quickly the body breaks down voriconazole. Taking schisandra with voriconazole might increase the effects and side effects of voriconazole.

Warfarin is used to slow blood clotting. Schisandra might increase the breakdown and decrease the effects of warfarin. Decreasing the effects of warfarin might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.