Clinical Benefits
Clinical Benefits
Metagenics, Joint Intensive Care is a comprehensive anti-inflammatory formula designed to target musculoskeletal inflammation through multiple pathways that address both pain and the underlying tissue damage that perpetuates chronic conditions. Musculoskeletal inflammation involves a complex cascade where inflammatory cytokines and matrix metalloproteinases (MMPs) work together to break down cartilage, tendons, and other connective tissues while amplifying pain signals throughout the body.
Turmeric extract, featuring both Turmacin™ and standardized curcuminoids at 95% potency, serves as the cornerstone of this formula's anti-inflammatory action. Curcumin, the principal bioactive compound in turmeric, targets multiple points in the inflammatory cascade, beginning with inhibition of toll-like receptor (TLR) signaling to prevent early activation of pro-inflammatory pathways. It also activates the nuclear receptor PPAR-γ, which suppresses NFκB activation, thereby reducing the transcription of pro-inflammatory cytokines. Additionally, curcumin downregulates pro-inflammatory enzymes such as COX-2 and LOX while inhibiting tissue-degrading matrix metalloproteinases, specifically MMP‑1, MMP‑3, and MMP‑13, helping preserve extracellular matrix integrity in cartilage and connective tissues [49][50]. A meta-analysis of 29 studies demonstrated that 1g per day of curcumin for 4-12 weeks produced pain and function improvements in arthritis comparable to NSAIDs [3][21][49]. In knee osteoarthritis specifically, a meta-analysis of 23 randomized controlled trials involving 2,175 patients showed that 500-2000 mg daily of curcumin for 4-12 weeks achieved pain relief comparable to NSAIDs with fewer adverse effects, 31% improvement in function and mobility, and an 83% reduction in the likelihood of needing additional medication [11].
Boswellia serrata extract, standardized for 3-O-Acetyl-11-Keto-β-boswellic acid, works synergistically with curcumin to provide comprehensive inflammatory control. Boswellia contains bioactive compounds known as boswellic acids which inhibit the messenger known as IKK in step 2 of inflammation, thereby limiting NFκB activation and downregulating the production of all inflammatory cytokine mediators. Furthermore, Boswellia has been clinically demonstrated to inhibit the production of MMP-3 and MMP13, which not only slows cartilage breakdown but also promotes an environment conducive to tissue repair [51]. In one study, 88 adults with musculoskeletal strain received 266 mg curcumin plus 1,000 mg boswellia, achieving relief in musculoskeletal pain within 63 minutes and a 53% reduction in pain, comparable to paracetamol and NSAIDs [1][3]. A study in patients with ankylosing spondylitis using 400 mg per day Boswellia extract plus curcumin over 28 days reported 30-40% estimated reduction in pain and stiffness versus placebo [46].
[3]>https://pubmed.ncbi.nlm.nih.gov/27533649/
[11]>https://www.sciencedirect.com/science/article/pii/S0378874123013636
[21]>https://pubmed.ncbi.nlm.nih.gov/32114280/
[43]>https://pmc.ncbi.nlm.nih.gov/articles/PMC5622718/
[45]>https://pmc.ncbi.nlm.nih.gov/articles/PMC8767078/
[46]>https://pmc.ncbi.nlm.nih.gov/articles/PMC9143056/
[49]>https://www.sciencedirect.com/science/article/abs/pii/S0367326X24000534
Ingredients
BCM-95™ Turmeric Curcuma longa (Turmeric)
ext. equiv. Curcumin
ext. equiv. dry (rhizome)
152 mg
106 mg
3.8 g
Quercetin
250 mg
Citrus bioflavonoids extract (Hesperidin)
100 mg
Capsicum frutescens (fruit) powder
25 mg
BosPure® Boswellia serrata ext.
ext. equiv. dry (gum oleoresin)
150 mg
1.5 g
Salix alba (Willow bark) ext.
ext. equiv. dry (stem bark)
60 mg
1.5 g
Zingiber officinale (Ginger) ext.
ext. equiv. dry (rhizome)
62.5 mg
500 mg
Instructions
Instructions
Dosage
2 - 4 capsules daily, dependant on pain
Duration
Suitable for long-term use, with dosing adjusted according to symptoms
Warnings
Dietary supplements should not replace a balanced diet
If symptoms persist, worsen or change unexpectedly, consult your healthcare professional
Contraindications
Contraindications
• Medications for cancer
• Medications for diabetes
• Medications for high blood pressure
• Medications moved by pumps in cells - see list
• Medications that can harm the liver
• Medications that slow blood clotting
• Medications that decrease the immune system
• Tacrolimus
• Talinolol
• Tamoxifen
• Tramadol
• Omeprazole
• Atorvastatin
• Simvastatin
• Amlodipine
• Diltiazem
• Cyclosporine
• Alprazolam
• Rivaroxaban
• Esomeprazole
• Clopidogrel
• Diazepam
• Escitalopram
• Sertraline
• Metoprolol
• Fluoxetine
• Paroxetine
• Amitriptyline
• Some HIV antiretrovirals
• Glipizide
• Phenytoin
• Losartan
• Midazolam
• Mitoxantrone
• Pravastatin
• Prazosin
• Quetiapine
• Acetazolamide
• Salsalate
Major Interactions
Moderate Interactions
Medications for cancer
• Cyclophosphamide (Cytoxan / Endoxan)
• Chlorambucil
• Melphalan
• Busulfan
• Temozolomide
• Doxorubicin
• Bleomycin
• Daunorubicin
• Mitomycin
• Epirubicin
Turmeric is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking turmeric.
Medications for diabetes
• Glyburide
• Glipizide
• Insulin
• Sitagliptin
• Empagliflozin
• Semaglutide
• Dapagliflozin
Turmeric and quercetin might lower blood sugar levels. Taking turmeric along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications for high blood pressure
• Amlodipine
• Ramipril (Altace / Tritace)
• Perindopril
• Metoprolol
• Losartan
• Hydrochlorothiazide
Quercetin might lower blood pressure. Taking quercetin along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Medications moved by pumps in cells
• Rosuvastatin
• Atorvastatin
• Simvastatin
• Methotrexate
• Fexofenadine
• Levothyroxine
Some medications are moved in and out of cells by pumps. Turmeric might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Medications that can harm the liver
• Acetaminophen / Paracetamol (Tylenol, Panadol)
• Methotrexate
• Atorvastatin
• Simvastatin
• Isoniazid
Turmeric might harm the liver. Some medications can also harm the liver. Taking turmeric along with a medication that can harm the liver might increase the risk of liver damage.
Medications that slow blood clotting
• Heparin
• Rivaroxaban
• Apixaban
• Dabigatran
• Clopidogrel
• Phenprocoumon
• Nifedipine
• Phenprocoumon
• Warfarin
Turmeric, ginger and Willowbark might slow blood clotting. Taking turmeric and willowbark along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications that decrease the immune system
• Cyclosporine
• Tacrolimus
• Mycophenolate
• Prednisone
• Methotrexate
• Azathioprine
Boswellia serrata can affect the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking Boswellia serrata along with these medications might alter the effects of these medications.
Methotrexate
Turmeric might harm the liver. Methotrexate can also harm the liver. Taking turmeric along with methotrexate might increase the risk of liver damage.
Sulfasalazine
Turmeric might increase how much sulfasalazine the body absorbs. Taking turmeric while taking sulfasalazine might increase the effects and side effects of sulfasalazine.
Tacrolimus
Turmeric might increase the amount of tacrolimus in the body. This can increase the side effects of tacrolimus and even damage the kidneys.
Talinolol
Turmeric might decrease how much talinolol the body absorbs. Taking turmeric while taking talinolol might decrease the effects of talinolol.
Tamoxifen
Turmeric might decrease how much tamoxifen is in the body. Taking turmeric with tamoxifen might decrease the effects of tamoxifen.
Tramadol
Turmeric might decrease or increase how much tramadol is in the body. Taking turmeric with tramadol might increase or decrease the effects of tramadol.
Medications changed by the liver
• Omeprazole (Losec / Prilosec)
• Atorvastatin
• Simvastatin
• Amlodipine
• Diltiazem
• Cyclosporine
• Tacrolimus
• Midazolam
• Alprazolam
• Rivaroxaban
• Esomeprazole
• Clopidogrel
• Diazepam
• Escitalopram
• Sertraline
• Tramadol
• Metoprolol
• Fluoxetine
• Paroxetine (Paxil/Aropax)
• Tamoxifen
• Amitriptyline
• Some HIV antiretrovirals
• Glipizide
• Phenytoin
• Losartan
Some medications are changed and broken down by the liver. Turmeric, Boswellia and Quercetin might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
Voltaren
Quercetin might decrease how quickly the body breaks down diclofenac. Taking quercetin with diclofenac might increase the effects and side effects of diclofenac.
Losartan
Quercetin might change how the body absorbs and breaks down losartan. Taking quercetin with losartan might change the effects and side effects of losartan.
P-glycoprotein substrates
Some medications are moved in and out of cells by pumps. Quercetin might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Midazolam
Quercetin might increase how quickly the body breaks down midazolam. Taking quercetin with midazolam might reduce the effects of midazolam.
Mitoxantrone
Quercetin might increase levels of mitoxantrone. Taking quercetin and mitoxantrone together might increase the effects and side effects of mitoxantrone.
Pravastatin
Quercetin might decrease how quickly the body gets rid of pravastatin. Taking quercetin with pravastatin might increase the effects and side effects of pravastatin.
Prazosin
Quercetin might increase levels of prazosin. Taking quercetin and prazosin together might increase the effects and side effects of prazosin.
Quetiapine
Quercetin might increase levels of quetiapine. Taking quercetin and quetiapine together might increase the effects and side effects of quetiapine.
Sulfasalazine
Quercetin might increase levels of sulfasalazine. Taking quercetin and sulfasalazine together might increase the effects and side effects of sulfasalazine.
Acetazolamide
Theoretically, willow bark might result in additive adverse effects associated with acetazolamide.
Willow bark contains salicin, a plant salicylate. Human case reports suggests that a combination of acetazolamide and salicylate increases unbound plasma levels of acetazolamide, as well as adverse effects related to acetazolamide.
Salsalate
Theoretically, willow bark might increase the effects and adverse effects of salsalate.
Willow bark contains salicin, a plant salicylate. It might have an additive effect when taken with other salicylate-containing drugs such as salsalate.
Minor Interactions
Docetaxel
Turmeric might increase how much docetaxel the body absorbs. Taking turmeric while taking docetaxel might increase the effects and side effects of docetaxel.
Estrogens
Large amounts of turmeric might interfere with the effects of estrogen. Taking turmeric along with estrogen might decrease the effects of estrogens. Some estrogen pills include conjugated equine estrogens, ethinyl estradiol, estradiol, and others.
Glyburide
Turmeric contains curcumin. Curcumin might lower blood sugar. Glyburide is also used to lower blood sugar. Taking curcumin or turmeric along with glyburide might cause your blood sugar to go too low. Monitor your blood sugar closely. Your dose of glyburide might need to be changed.
Norfloxacin
Turmeric might increase how much norfloxacin the body absorbs. Taking turmeric while taking norfloxacin might increase the effects and side effects of norfloxacin.
Paclitaxel
Turmeric might change how much paclitaxel stays in the body. Taking turmeric while taking paclitaxel might change the effects and side effects of paclitaxel. However, this doesn't seem to be a big concern.
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• Curcumin provides pain relief comparable to NSAIDs with 31% improvement in function and 83% reduction in need for additional medication
• Boswellia delivers rapid pain relief within 63 minutes and 53% pain reduction comparable to pharmaceutical painkillers
• Combined formula targets multiple inflammatory pathways while inhibiting tissue-degrading enzymes that break down cartilage and connective tissue