Clinical Benefits
Clinical Benefits
Gut Inflam X targets intestinal permeability through a comprehensive blend of clinically-researched ingredients that address the multiple pathways involved in maintaining gut barrier integrity. When the intestinal lining becomes compromised, allowing harmful substances to pass through into systemic circulation, it can trigger widespread inflammatory responses affecting skin health, immune function, digestive comfort, and overall vitality.
Zinc carnosine (Polaprezinc) serves as a cornerstone ingredient for intestinal repair, with unique properties that allow it to adhere specifically to damaged mucosal tissue where it releases zinc locally to promote healing. Zinc is essential for epithelial cell restitution - the initial step in wound healing - and cells deficient in zinc show decreased expression of critical tight junction proteins zonulin and occludin, which maintain barrier integrity. Zinc carnosine's superior bioavailability and targeted delivery to inflamed tissue makes it particularly effective for supporting mucosal repair compared to other zinc forms [21],[31]. Additionally, zinc deficiency increases cellular death and is found in up to 40% of inflammatory bowel disease cases, highlighting its crucial role in moderating intestinal inflammation [13].
The formula combines powerful anti-inflammatory botanicals including BosPure® Boswellia serrata and Andrographis paniculata, which work synergistically to address the inflammatory cascades that compromise gut barrier function. When inflammation occurs due to factors like dysbiosis, food sensitivities, or chronic infection, immune signals such as TNF-alpha trigger enzymes called matrix metalloproteinases that break down the structural proteins supporting the intestinal wall. This weakens the gut barrier and increases permeability, allowing microorganisms, food particles and endotoxins to enter circulation inappropriately [13]. The standardized andrographolide content in Andrographis provides potent anti-inflammatory effects that help modulate these destructive pathways.
Coptis chinensis, standardized for berberine content, contributes additional barrier-protective benefits through its antimicrobial and anti-inflammatory properties. Dysbiosis, characterized by an imbalance of pathogenic to beneficial bacteria, directly contributes to intestinal permeability because harmful bacteria such as E.coli, Salmonella and Clostridium trigger the release of zonulin, which loosens the tight junctions between intestinal cells [15]. By helping restore microbial balance, berberine-containing botanicals support the maintenance of proper barrier function.
The inclusion of Vitamin D3 (cholecalciferol) addresses a key nutritional factor in barrier maintenance, as vitamin D binds to vitamin D receptors that are highly expressed throughout the gut. These receptors help regulate genes involved in gut immunity and barrier protection, including tight junction proteins like claudins, zonulin and occludins. Vitamin D deficiency has been shown to compromise intestinal barrier function and promote intestinal permeability, while adequate levels are necessary for epithelial cell restoration and maintaining healthy barrier function [21],[24]. Zingiber officinale (ginger) rounds out the formula with its well-established anti-inflammatory and digestive supportive properties, helping to calm intestinal irritation while supporting overall gastrointestinal comfort and function.
Ingredients
Zinc carnosine (Polaprezinc)
equiv. Zinc
28 mg
6.25 mg
Cholecalciferol (Vitamin D3)
equiv. Vitamin D3
6.25 µg
250 IU
Andrographis paniculata ext.
equiv. Andrographolides
ext. equiv. dry (herb top)
160 mg
22 mg
2.6 g
BosPure® Boswellia serrata ext.
ext. equiv. dry (gum oleoresin)
75 mg
750 mg
Coptis chinensis (Chinese goldthread) ext.
equiv. Berberine
ext. equiv. dry (rhizome)
167 mg
50 mg
1.7 g
Zingiber officinale (Ginger) ext.
ext. equiv. dry (rhizome)
18 mg
748 mg
Instructions
Instructions
Dosage
2 capsules twice daily
Duration
4 weeks
Suitable for long-term managment in cases of inflammatory bowel disease
Warnings
Always read the label
Dietary supplements should not replace a balanced diet
If symptoms persist, worsen or change unexpectedly, consult your healthcare professional
Contains zinc which may be dangerous if taken in large amounts or for a long period
Andrographis may cause taste disturbance, including loss of taste, loss of appetite, vomiting and abdominal discomfort
If you develop any adverse symptoms, stop taking the product as soon as possible and seek medical advice
Andrographis may cause allergic reactions in some people; if you have a severe reaction (such as anaphylaxis) stop use and seek immediate medical attention
Contraindications
Contraindications
This supplement may interact with the following categories of medications, as well as specific active ingredients.
• Medications for high blood pressure
• Medications that decrease the immune system
• Medications that slow blood clotting
• Etoricoxib
• Glipizide
• Antibiotics
• Bictegravir/emtricitabine/tenofovir alafenamide
• Cephalexin
• Cisplatin
• Medications for HIV/AIDS
• Penicillamine
• Ritonavir
• Atazanavir
• Losartan
• Medications for diabetes
• Nifedipine
• Phenprocoumon
• Warfarin
• Medications changed by the liver - refer list
• Medications moved by pumps in cells - refer list
• Metronidazole
• Atorvastatin
• Calcipotriene
• Digoxin
• Diltiazem
• Verapamil
• Diuretics
Further details are provided below.
Please note that medications may be sold under different brand names, so check the listed active ingredients against your medication packaging.
Major Interactions
Moderate Interactions
Medications for high blood pressure
• Amlodipine
• Ramipril
• Perindopril
• Metoprolol
• Losartan
• Hydrochlorothiazide
Andrographis might lower blood pressure. Taking andrographis along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Medications that decrease the immune system
• Cyclosporine
• Tacrolimus
• Mycophenolate
• Prednisone
• Methotrexate
• Azathioprine
Andrographis can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking Andrographis along with these medications might decrease the effects of these medications.
Medications that slow blood clotting
• Heparin
• Rivaroxaban
• Apixaban
• Dabigatran
• Clopidogrel
Andrographis might slow blood clotting. Taking andrographis along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Antibiotics
• Doxycycline
• Ciprofloxacin
• Amoxicillin
• Azithromycin
• Norfloxacin
• Trimethoprim
Zinc might decrease how much antibiotic the body absorbs from the gut. Taking zinc along with quinolone antibiotics might decrease the effects of these antibiotics. To avoid this interaction, take antibiotics at least 2 hours before or 4-6 hours after zinc supplements.
Zinc can decrease the amount of tetracyclines the body absorbs. Taking zinc with tetracyclines might decrease the effects of tetracyclines. To avoid this interaction, take tetracyclines 2 hours before or 4-6 hours after taking zinc supplements.
Bictegravir/emtricitabine/tenofovir alafenamide
• Biktarvy
In theory, zinc might decrease how much bictegravir/emtricitabine/tenofovir alafenamide the body absorbs from the stomach. To avoid this interaction, take bictegravir/emtricitabine/tenofovir alafenamide at least 2 hours before or 6 hours after zinc containing products.
Cephalexin
• Keflex
Zinc can reduce how much cephalexin the body absorbs. This might decrease how well cephalexin works for treating infections. To avoid this interaction, take zinc 3 hours after taking cephalexin.
Cisplatin
• Platinol-AQ
Cisplatin is used to treat cancer. Taking zinc along with cisplatin might inactivate cisplatin therapy. But it's not clear if this is a big concern.
Medications for HIV/AIDS
• Integrase inhibitors
Taking zinc along with integrase inhibitors might decrease blood levels of integrase inhibitors. This might decrease the effects of these medications. Talk to your healthcare provider if you are using integrase inhibitors and want to start taking zinc.
Penicillamine
• Cuprimine, Depen
Zinc might decrease how much penicillamine the body absorbs. Taking zinc with penicillamine might decrease the effects of penicillamine. Take zinc and penicillamine at least 2 hours apart.
Ritonavir
• Norvir
Ritonavir is a drug used for HIV infection. Zinc can reduce how much ritonavir the body absorbs. But it isn't clear if this is a big concern.
Losartan
• Cozaar
• Hyzaar
• Used for: high blood pressure, heart failure
Ginger can increase how much losartan the body absorbs. Taking ginger along with losartan might increase the effects and side effects of losartan.
Medications for diabetes
• Glyburide
• Glipizide
• Insulin
• Sitagliptin
• Empagliflozin
• Semaglutide
• Dapagliflozin
Ginger might lower blood sugar levels. Taking ginger along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Ginger might slow blood clotting. Taking ginger along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Nifedipine
• Procardia
Taking ginger along with nifedipine might slow blood clotting and increase the chances of bruising and bleeding.
Phenprocoumon
• Marcoumar, others
Phenprocoumon is used to slow blood clotting. Ginger can also slow blood clotting. Taking ginger along with phenprocoumon might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your phenprocoumon might need to be changed.
• Jantoven
• Used for: blood thinning, clot prevention
Warfarin is used to slow blood clotting. Ginger can also slow blood clotting. Taking ginger along with warfarin might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Atorvastatin
Vitamin D might decrease how much atorvastatin the body absorbs. Taking vitamin D with atorvastatin might decrease the effects of atorvastatin.
Calcipotriene
• Dovonex
Taking vitamin D along with calcipotriene might increase the effects and side effects of calcipotriene.
• Used for: heart failure, atrial fibrillation
Taking vitamin D along with digoxin might increase the effects and side effects of digoxin. If you are taking digoxin, talk to your doctor before taking vitamin D supplements.
Diltiazem
• Cardizem, others
Vitamin D helps your body absorb calcium. Calcium can affect the heart. Diltiazem can also affect the heart. Taking large amounts of vitamin D along with diltiazem might decrease the effects of diltiazem.
Verapamil
• Calan, others
Vitamin D helps the body absorb calcium. Calcium can affect the heart. Verapamil can also affect the heart. Do not take large amounts of vitamin D if you are taking verapamil.
Diuretics
• Thiazide diuretics
Vitamin D helps the body absorb calcium. Some "Diuretics" increase the amount of calcium in the body. Taking large amounts of vitamin D along with some "Diuretics" might cause too much calcium in the body. This could cause serious side effects, including kidney problems.
Medications changed by the liver
• Atorvastatin
• Simvastatin
• Amlodipine
• Diltiazem
• Cyclosporine
• Tacrolimus
• Midazolam
• Alprazolam
• Rivaroxaban
• Some HIV antiretrovirals
Some medications are changed and broken down by the liver. Goldthread might decrease how quickly the liver breaks down some medications. Taking goldthread along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking goldthread, talk to your healthcare provider if you are taking any medications that are changed by the liver. Some medications changed by the liver include cyclosporine, lovastatin, clarithromycin, indinavir, sildenafil, triazolam, and many others.
Minor Interactions
Etoricoxib
• Arcoxia
Andrographis might decrease the amount of etoricoxib in the body. It is not clear if this will impact the effects of etoricoxib.
Glipizide
• Glucotrol
Andrographis might change the amount of glipizide in the body. It is not clear if this will impact the effects of glipizide.
Atazanavir
• Reyataz
Atazanavir is a drug used for HIV infection. Zinc decreases how much atazanavir the body absorbs. But the body still absorbs enough atazanavir for it to work for treating HIV. So this interaction is probably not a big concern.
Medications changed by the liver
• Caffeine
• Clozapine
• Olanzapine
• Theophylline
• Tizanidine
• Duloxetine
• Ramelteon
Some medications are changed and broken down by the liver. Ginger might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
• Cytochrome P450 2B6 substrates
• Warfarin
• Ibuprofen
• Diclofenac
• Glipizide
• Phenytoin
• Losartan
• Celecoxib
• Atorvastatin
• Simvastatin
• Amlodipine
• Diltiazem
• Cyclosporine
• Tacrolimus
• Midazolam
• Alprazolam
• Rivaroxaban
• Some HIV antiretrovirals
Medications for high blood pressure
• Amlodipine
• Diltiazem
• Verapamil
• Felodipine
• Nifedipine
Ginger might lower blood pressure. Taking ginger along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Medications moved by pumps in cells
• Digoxin
• Dabigatran
• Cyclosporine
• Fexofenadine
• Loperamide
• Some HIV antiretrovirals
Some medications are moved in and out of cells by pumps. Ginger might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Metronidazole
• Flagyl
Ginger can increase how much metronidazole the body absorbs. Taking ginger along with metronidazole might increase the effects and side effects of metronidazole.
Some medications are changed and broken down by the liver. Vitamin D might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.
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• Contains zinc carnosine with superior mucosal adhesion properties for targeted intestinal repair and tight junction protein restoration
• Features clinically-researched anti-inflammatory botanicals that help modulate TNF-alpha and other inflammatory pathways that damage gut barrier integrity
• Includes vitamin D3 to support tight junction protein expression and epithelial cell restoration, addressing a key nutritional deficiency linked to increased intestinal permeability