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Clinical Benefits

Clinical Benefits

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Digestive Zyme targets biofilms, the protective bacterial and fungal communities that shield harmful microorganisms from immune detection and antimicrobial treatments. These organized microbial communities, composed of sugars, proteins, lipids, and extracellular DNA, can make pathogens 10 to 1000 times more tolerant to antimicrobial treatments [2]. By disrupting these protective matrices, this formula aims to expose hidden pathogens and support the body's natural defense mechanisms.

Berberis vulgaris (Barberry) provides berberine, a powerful biofilm disruptor that blocks bacterial adhesion to surfaces at the cellular level. Berberine downregulates genes responsible for sticky surface proteins (adhesins) and reduces extracellular polymeric substance (EPS) matrix production, while affecting bacterial metabolic pathways critical for biofilm maintenance. Research demonstrates that berberine weakens mature biofilms and increases the effectiveness of antibiotics, making it harder for bacteria to survive within their protective communities.

Zingiber officinale (Ginger) contains active compounds that support digestive function and may help reduce inflammation associated with biofilm-related infections. The anti-inflammatory properties of ginger can help address the chronic inflammatory response that occurs when biofilms create 'frustrated phagocytosis' - a state where immune cells cannot effectively attack protected pathogens. Cynara scolymus (Globe artichoke) supports liver function and bile production, which is particularly relevant since biofilms in the digestive tract can trap bile acids, leading to digestive dysfunction and diarrhea in conditions like irritable bowel syndrome [7].

The enzyme complex of protease, tilactase, and lipase works synergistically to break down biofilm structural components. Protease enzymes specifically target the protein fibers that bacteria use to hold biofilm matrices together. This structural weakening allows antibiotics and immune cells to penetrate and eliminate the bacteria. Studies show protease therapies improve wound healing, reduce infection rates, and accelerate the breakdown of biofilm-contaminated tissues. The inclusion of tilactase and lipase supports comprehensive digestion while potentially affecting the lipid and carbohydrate components of biofilm matrices.

Taurine and glycine serve as important amino acids that support cellular function and may help protect tissues from the oxidative damage associated with chronic biofilm infections. These amino acids can support glutathione production and cellular repair processes, helping to restore normal tissue function once biofilms are disrupted. Together, this comprehensive formula addresses multiple aspects of biofilm disruption while supporting digestive health and immune function.

Ingredients

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Berberis vulgaris (Barberry) ext.
ext. equiv. dry (stem bark)

83.33 mg
500 mg

Zingiber officinale (Ginger) ext.
ext. equiv. dry (rhizome)

50 mg
250 mg

Cynara scolymus (Globe artichoke) ext.
ext. equiv. fresh (leaf)

5 mg
250 mg

Taurine

10 mg

Glycine

10 mg

Protease

115000 HUT

Tilactase

2000 ALU

Lipase

63 LipU

Instructions

Instructions

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Dosage

1 tablet morning, 2 tablets night with food


Duration

4 weeks

Warnings

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Always read the label
Dietary supplements should not replace a balanced diet
If symptoms persist, worsen or change unexpectedly, consult your healthcare professional

Contraindications

Contraindications

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This supplement may interact with the following categories of medications, as well as specific active ingredients.

• Medications for depression
• Estrogens
• Levothyroxine
• Medications for diabetes
• Medications for high blood pressure
• Tamoxifen
• Warfarin
• Diuretics
• Medications changed by the liver - refer list
• Medications that slow blood clotting
• Sedative medications
• Various medications used for glaucoma, Alzheimer disease, and other conditions
• Losartan
• Nifedipine
• Phenprocoumon
• Medications moved by pumps in cells - refer list
• Metronidazole

Further details are provided below.

Please note that medications may be sold under different brand names, so check the listed active ingredients against your medication packaging.

Major Interactions

Medications for depression

• MAOIs


Fermented soy products such as tofu and soy sauce contain tyramine. Tyramine is a naturally occurring chemical that is involved in blood pressure regulation. MAOIs can decrease how quickly the body breaks down tyramine. Consuming more than 6 mg of tyramine while taking one of these medications can increase the risk of serious side effects, such as very high blood pressure. If you take one of these medications, avoid fermented soy products that contain high amounts of tyramine. Some common MAOIs include phenelzine, selegiline, and tranylcypromine.

Moderate Interactions

Caffeine


Soy contains the chemical genistein. Genistein might slow down how quickly the body gets rid of caffeine. This might increase the effects of caffeine.


Estrogens


• Oral contraceptive pill

• Estradiol

• Conjugated estrogens

• HRT combination products


Large amounts of soy might have some of the same effects as estrogen. Taking soy along with estrogen pills might decrease the effects of estrogen pills.


Levothyroxine


• Synthroid, others


Levothyroxine is used for low thyroid function. Soy seems to decrease how much levothyroxine is absorbed by the body in infants, but not adults. This might decrease the effects of levothyroxine in infants. The dose of levothyroxine may need to be adjusted if soy is being used regularly, such as in soy-based formulas. Otherwise, take levothyroxine and soy at least 4 hours apart.


Medications for diabetes


• Glyburide

• Glipizide

• Insulin

• Sitagliptin

• Empagliflozin

• Semaglutide

• Dapagliflozin


Soy might lower blood sugar levels. Taking soy along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.


Medications for high blood pressure


• Amlodipine

• Ramipril

• Perindopril

• Metoprolol

• Losartan

• Hydrochlorothiazide


Soy might lower blood pressure. Taking soy along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.


Progesterone


Some research shows that taking soy milk along with progesterone might increase bone loss in females with osteoporosis.


Tamoxifen


• Soltamox

• Used for: breast cancer treatment and prevention


Tamoxifen affects the activity of estrogen in the body. Soy seems to also affect estrogen activity in the body. Taking soy with tamoxifen might change the effects of tamoxifen. Speak with a healthcare provider if you are taking tamoxifen.



• Jantoven

• Used for: blood thinning, clot prevention


Warfarin is used to slow blood clotting. Soy has been reported to decrease the effects of warfarin. This might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.


Diuretics


• Diuretic drugs


Soy can increase urine production. The effects seem to be similar to those of "Diuretics. " Taking soy along with "Diuretics" might increase the risk for side effects.


Medications changed by the liver


• Omeprazole

• Esomeprazole

• Clopidogrel

• Diazepam

• Escitalopram

• Sertraline


Some medications are changed and broken down by the liver. Artichoke might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.


Artichoke might lower blood sugar levels. Taking artichoke along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.


Artichoke might lower blood pressure. Taking artichoke along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.


Taurine might lower blood pressure. Taking taurine along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.


Drying medications


• Anticholinergic drugs


European barberry can block a chemical in the body called acetylcholine, which has many important functions. Some medications, called anticholinergic drugs, also block acetylcholine. There is some concern that taking them together might increase the risk for confusion, blurred vision, increased sweating, and increased heart rate.


• Atorvastatin

• Simvastatin

• Amlodipine

• Diltiazem

• Cyclosporine

• Tacrolimus

• Midazolam

• Alprazolam

• Rivaroxaban

• Some HIV antiretrovirals


Some medications are changed and broken down by the liver. European barberry might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.


European barberry might lower blood sugar levels. Taking European barberry along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.


European barberry might lower blood pressure. Taking European barberry along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.


Medications that slow blood clotting


• Heparin

• Rivaroxaban

• Apixaban

• Dabigatran

• Clopidogrel


European barberry might slow blood clotting. Taking European barberry along with medications that also slow blood clotting might increase the risk of bruising and bleeding.


Sedative medications


• Diazepam

• Alprazolam

• Temazepam

• Zolpidem

• Zopiclone

• Promethazine


European barberry might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking European barberry with sedative medications might cause breathing problems and/or too much sleepiness.


Various medications used for glaucoma, Alzheimer disease, and other conditions


• Cholinergic drugs


Some medications that are used for glaucoma, Alzheimer disease, and other conditions increase acetylcholine levels. But European barberry can block acetylcholine. Taking European barberry with these medications might decrease the effects of these drugs.


Losartan


• Cozaar

• Hyzaar

• Used for: high blood pressure, heart failure


Ginger can increase how much losartan the body absorbs. Taking ginger along with losartan might increase the effects and side effects of losartan.


Ginger might lower blood sugar levels. Taking ginger along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.


Ginger might slow blood clotting. Taking ginger along with medications that also slow blood clotting might increase the risk of bruising and bleeding.


Nifedipine


• Procardia


Taking ginger along with nifedipine might slow blood clotting and increase the chances of bruising and bleeding.


Phenprocoumon


• Marcoumar, others


Phenprocoumon is used to slow blood clotting. Ginger can also slow blood clotting. Taking ginger along with phenprocoumon might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your phenprocoumon might need to be changed.


Warfarin is used to slow blood clotting. Ginger can also slow blood clotting. Taking ginger along with warfarin might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.

Minor Interactions

Medications changed by the liver


• Caffeine

• Clozapine

• Olanzapine

• Theophylline

• Tizanidine

• Duloxetine

• Ramelteon


Some medications are changed and broken down by the liver. Ginger might change how quickly the liver breaks down these medications. If you are taking medications metabolised by the liver, monitor for any changes in how your medication affects you.


• Cytochrome P450 2B6 substrates


• Warfarin

• Ibuprofen

• Diclofenac

• Glipizide

• Phenytoin

• Losartan

• Celecoxib


• Atorvastatin

• Simvastatin

• Amlodipine

• Diltiazem

• Cyclosporine

• Tacrolimus

• Midazolam

• Alprazolam

• Rivaroxaban

• Some HIV antiretrovirals


Medications for high blood pressure


• Amlodipine

• Diltiazem

• Verapamil

• Felodipine

• Nifedipine


Ginger might lower blood pressure. Taking ginger along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.


Medications moved by pumps in cells


• Digoxin

• Dabigatran

• Cyclosporine

• Fexofenadine

• Loperamide

• Some HIV antiretrovirals


Some medications are moved in and out of cells by pumps. Ginger might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.


Metronidazole


• Flagyl


Ginger can increase how much metronidazole the body absorbs. Taking ginger along with metronidazole might increase the effects and side effects of metronidazole.

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• Contains berberine which weakens mature biofilms and increases antibiotic effectiveness by blocking bacterial adhesion

• Protease enzymes break down protein fibers that hold biofilm matrices together, allowing immune cells to penetrate

• Targets biofilms that make pathogens 10-1000 times more resistant to antimicrobial treatments

Digestive Zyme

InterClinical

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